YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SCC2

General Information:
Name(s) found: SCC2 / YDR180W [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1493 amino acids

    Gene Ontology:
    Cellular Component: nuclear cohesin complex [TASLink to PubMed article]
    Biological Process: mitotic sister chromatid cohesion [IMPLink to PubMed article][TASLink to PubMed article]
    double-strand break repair via homologous recombination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYPGKDKNI PGRIIEALED LPLSYLVPKD GLAALVNAPM RVSLPFDKTI FTSADDGRDV  60
   61 NINVLGTANS TTSSIKNEAE KERLVFKRPS NFTSSANSVD YVPTNFLEGL SPLAQSVLST 120
  121 HKGLNDSINI EKKSEIVSRP EAKHKLESVT SNAGNLSFND NSSNKKTKTS TGVTMTQANL 180
  181 AEQYLNDLKN ILDIVGFDQN SAEIGNIEYW LQLPNKKFVL TTNCLTKLQM TIKNITDNPQ 240
  241 LSNSIEITWL LRLLDVMVCN IKFSKSSLKM GLDDSMLRYI ALLSTIVLFN IFLLGKNDSN 300
  301 LHRESYIMEP VNFLSDLIES LKILTIEYGS LKIEFDTFQE ALELLPKYIR NGPFLDDNVT 360
  361 AKLVYIFSDL LMNNDIEATT NIQFQSFWDN VKRISSDILV SLFGSFDQQR GFIIEELLSH 420
  421 IEKLPTKRIQ KKLRKVGNQN IYITDFTFTL MSMLENINCY SFCNQMKDIA PENIDLLKNE 480
  481 YKKQEEFLFN IVEHINDTIL ERFFKNPSAL RYVIDNFVQD LLLLISSPQW PVTEKILSSL 540
  541 LKRLLSVYSP SMQVSANIET ICLQLIGNIG STIFDIKCST RDHEDNNLIK MINYPETLPH 600
  601 FFKSFEECIA YNETIKCRRS ATRFLWNLRL GTILILEEYT KDAKEQIITV DNELKKILEQ 660
  661 IKDGGLGPEL ENREADFSTI KLDYFSILHA FELLNLYDPY LKLILSLLAK DKIKLRSTAI 720
  721 KCLSMLASKD KVILSNPMVK ETIHRRLNDS SASVKDAILD LVSINSSYFE FYQQINNNYN 780
  781 DDSIMVRKHV LRINEKMYDE TNDIVTKVYV IARILMKIED EEDNIIDMAR LILLNRWILK 840
  841 VHEVLDQPEK LKEISSSVLL VMSRVAIMNE KCSQLFDLFL NFYLLNKEAH SKEAYDKITH 900
  901 VLTILTDFLV QKIVELNSDD TNEKNSIVDK QNFLNLLAKF ADSTVSFLTK DHITALYPYM 960
  961 VSDEKSDFHY YILQVFRCTF EKLANFKQKF LYDLETTLLS RLPKMNVREI DEAMPLIWSV1020
 1021 ATHRHDTARV AKACSSCLSH LHPYINKANN EEAAIVVDGK LQRLIYLSTG FARFCFPKPS1080
 1081 NDKIAFLQEG ETLYEHITKC LLVLSKDKIT HVIRRVAVKN LTKLCGNHPK LFNSRHVLHL1140
 1141 LDKEFQSDQL DIKLVILESL YDLFLLEERK SVRNTGVNST LSSNSILKKK LLKTNRVEFA1200
 1201 NDGVCSALAT RFLDNILQLC LLRDLKNSLV AIRLLKLILK FGYTNPSHSI PTVIALFAST1260
 1261 SQYIRHVAYE LLEDLFEKYE TLVFSSLSRG VTKAIHYSIH TDEKYYYKHD HFLSLLEKLC1320
 1321 GTGKKNGPKF FKVLKRIMQS YLDDITDLTS TNSSVQKSIF VLCTNISNIT FVSQYDLVSL1380
 1381 LKTIDLTTDR LKEVIMDEIG DNVSSLSVSE EKLSGIILIQ LSLQDLGTYL LHLYGLRDDV1440
 1441 LLLDIVEESE LKNKQLPAKK PDISKFSAQL ENIEQYSSNG KLLTYFRKHV KDT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) IRR1 MCD1 REC8 SCC2 SMC1 SMC3
    View Details Krogan NJ, et al. (2006) MDJ1 SCC2 SCC4
    View Details Qiu et al. (2008) IRR1 MCD1 SCC2 SMC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SCC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..354] deduced N/A No confident structure predictions are available.
    2 View Details [355..1408] MSA 1.007903 View MSA. No confident structure predictions are available.
    3 View Details [1409..1493] deduced N/A No confident structure predictions are available.
    4 View Details [381..480] MSA 1.033993 View MSA. No confident structure predictions are available.
    5 View Details [481..1309] FFAS03 3.13 No description for 2ie3A was found.
    6 View Details [1310..1493] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.81296846555705 bayes_pls_golite062009
  • protein transporter activity
    		•  2.6734690782599 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.78701774446386 bayes_pls_golite062009
  • transporter activity
    		•  1.44589191111517 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.19535295481088 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08645493064764 bayes_pls_golite062009
  • DNA binding
    		•  0.956143892328242 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.824035252349223 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.384349606267362 bayes_pls_golite062009
  • transcription factor activity
    		•  0.371244009721798 bayes_pls_golite062009
  • RNA binding
    		•  0.369141052569571 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.338017015160581 bayes_pls_golite062009
  • signal sequence binding
    		•  0.262155773896291 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.19122877456451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.0946244209704199 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle