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Protein Overview: REC8

General Information:
Name(s) found: REC8 / YPR007C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 680 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome, centromeric region [IDALink to PubMed article]
    nuclear cohesin complex [IDALink to PubMed article]
    Biological Process: sister chromatid cohesion [TASLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPLSLNFKD DKKYKGLTTV WLLSALGNSI VKESNNYYSN KSNSTGNISS STVKKKDIVN  60
   61 ISIPKTCDEI QNFENDFSLR YISNLLYGVT ICYNKKTEYV LNDLNHLLVQ LQKNDVYAFK 120
  121 AKNKSTRING LNSNNSIIGN KNNNYTWEEC VFFDDDPLYD ITKVPALEFL NTTLQDNVSF 180
  181 IEEAKSIRRQ DYINELSNSN RFELHGDMTN SDAQSNLGSN VRNSFPLDEI PVDVDFNLDL 240
  241 DDIVSHQGTP LGSHSSSQKD GNDFKFNYQG DELVLNFEND NENNSNGGED TSVENEGPVA 300
  301 NLKDYELGLE AQASEEENDL QQKLNTRMQR GHRADVGGQF SKVQFDAKTS YPNEVLKFNH 360
  361 GNYSHLMEKN RIRKLTGQNF LTSNISSLVR SCGEEEFFST NWLSIFNDFS NIKTSEWDLY 420
  421 PQGFSSVERG RKRAHSLVST QSSSSTRSHE YGRKSFRNNK NDNYSSDMEN DNLLLNLEQI 480
  481 NEDLEDGHYI EENSQGNILD FNLNLPPSSF GRSHTRNSTR SSGFNEDIVG ALRRRVGPSE 540
  541 QNFAEEDDSS NSCFSDGSQQ NLQQDKTNFQ DVILDYQTKK FYDYIKERSI VVGRTTRSNP 600
  601 PFKRKMLLVD IIPSRMGEAQ TGANFDDVER GVSRQIAASA FLSLLNLATK GMVKLNEYPV 660
  661 ADAVTKDLKL RREDEIIVYA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) IRR1 MCD1 REC8 SCC2 SMC1 SMC3
    View Details Krogan NJ, et al. (2006) OCA4 OCA5 REC8
    View Details Qiu et al. (2008) HSK3 IRR1 REC8 SMC3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..680] deduced N/A No confident structure predictions are available.
    2 View Details [206..297] deduced N/A No confident structure predictions are available.
    3 View Details [298..549] deduced N/A No confident structure predictions are available.
    4 View Details [550..680] FFAS03 2.06 Sc Smc1hd:Scc1-C complex, ATPgS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  3.43291559958598 bayes_pls_golite062009
  • DNA binding
    		•  3.3647397700181 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.2907348579166 bayes_pls_golite062009
  • binding
    		•  3.2287204659268 bayes_pls_golite062009
  • transcription factor activity
    		•  2.56149193357611 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.29833348412438 bayes_pls_golite062009
  • transcription activator activity
    		•  1.12578574440827 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.975119185383629 bayes_pls_golite062009
  • protein binding
    		•  0.933833716716586 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.815066484495067 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.685909148192434 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.516581502758384 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.295322409391238 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle