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View Structure Prediction Details

Protein: REC8
Organism: Saccharomyces cerevisiae
Length: 680 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REC8.

Description E-value Query
Range
Subject
Range
gi|190407951 - gi|190407951|gb|EDV11216.1| hypothetical protein SCRG_02496 [Saccharomyces cerevisiae RM11-1a]
gi|207340421 - gi|207340421|gb|EDZ68776.1| YPR007Cp-like protein [Saccharomyces cerevisiae AWRI1631]
REC8_YEAST - Meiotic recombination protein REC8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=REC8 ...
REC8 - Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister c...
0.0 [1..680] [1..680]
SCC13_ARATH - Sister chromatid cohesion 1 protein 3 OS=Arabidopsis thaliana GN=SYN3 PE=2 SV=2
0.005 [53..107] [27..81]

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Predicted Domain #1
Region A:
Residues: [1-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPLSLNFKD DKKYKGLTTV WLLSALGNSI VKESNNYYSN KSNSTGNISS STVKKKDIVN  60
   61 ISIPKTCDEI QNFENDFSLR YISNLLYGVT ICYNKKTEYV LNDLNHLLVQ LQKNDVYAFK 120
  121 AKNKSTRING LNSNNSIIGN KNNNYTWEEC VFFDDDPLYD ITKVPALEFL NTTLQDNVSF 180
  181 IEEAKSIRRQ DYINELSNSN RFELHGDMTN SDAQSNLGSN VRNSFPLDEI PVDVDFNLDL 240
  241 DDIVSHQGTP LGSHSSSQKD GNDFKFNYQG DELVLNFEND NENNSNGGED TSVENEGPVA 300
  301 NLKDYELGLE AQASEEENDL QQKLNTRMQR GHRADVGGQF SKVQFDAKTS YPNEVLKFNH 360
  361 GNYSHLMEKN RIRKLTGQNF LTSNISSLVR SCGEEEFFST NWLSIFNDFS NIKTSEWDLY 420
  421 PQGFSSVERG RKRAHSLVST QSSSSTRSHE YGRKSFRNNK NDNYSSDMEN DNLLLNLEQI 480
  481 NEDLEDGHYI EENSQGNILD FNLNLPPSSF GRSHTRNSTR SSGFNEDIVG ALRRRVGPSE 540
  541 QNFAEEDDSS NSCFSDGSQQ NLQQDKTNFQ DVILDYQTKK FYDYIKERSI VVGRTTRSNP 600
  601 PFKRKMLLVD IIPSRMGEAQ TGANFDDVER GVSRQIAASA FLSLLNLATK GMVKLNEYPV 660
  661 ADAVTKDLKL RREDEIIVYA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [206-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDMTNSDAQS NLGSNVRNSF PLDEIPVDVD FNLDLDDIVS HQGTPLGSHS SSQKDGNDFK  60
   61 FNYQGDELVL NFENDNENNS NGGEDTSVEN EG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [298-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVANLKDYEL GLEAQASEEE NDLQQKLNTR MQRGHRADVG GQFSKVQFDA KTSYPNEVLK  60
   61 FNHGNYSHLM EKNRIRKLTG QNFLTSNISS LVRSCGEEEF FSTNWLSIFN DFSNIKTSEW 120
  121 DLYPQGFSSV ERGRKRAHSL VSTQSSSSTR SHEYGRKSFR NNKNDNYSSD MENDNLLLNL 180
  181 EQINEDLEDG HYIEENSQGN ILDFNLNLPP SSFGRSHTRN STRSSGFNED IVGALRRRVG 240
  241 PSEQNFAEED DS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [550-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSCFSDGSQ QNLQQDKTNF QDVILDYQTK KFYDYIKERS IVVGRTTRSN PPFKRKMLLV  60
   61 DIIPSRMGEA QTGANFDDVE RGVSRQIAAS AFLSLLNLAT KGMVKLNEYP VADAVTKDLK 120
  121 LRREDEIIVY A

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.06
Match: 1w1wE
Description: Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.43291559958598 bayes_pls_golite062009
DNA binding 3.3647397700181 bayes_pls_golite062009
nucleic acid binding 3.2907348579166 bayes_pls_golite062009
binding 3.2287204659268 bayes_pls_golite062009
transcription factor activity 2.56149193357611 bayes_pls_golite062009
sequence-specific DNA binding 1.29833348412438 bayes_pls_golite062009
transcription activator activity 1.12578574440827 bayes_pls_golite062009
transcription repressor activity 0.975119185383629 bayes_pls_golite062009
protein binding 0.933833716716586 bayes_pls_golite062009
structure-specific DNA binding 0.815066484495067 bayes_pls_golite062009
DNA-dependent ATPase activity 0.685909148192434 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.516581502758384 bayes_pls_golite062009
DNA helicase activity 0.295322409391238 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle