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Protein Overview: LYS2

General Information:
Name(s) found: LYS2 / YBR115C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1392 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][NASLink to PubMed article]
    Biological Process: lysine biosynthetic process via aminoadipic acid [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: L-aminoadipate-semialdehyde dehydrogenase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNEKVWIEK LDNPTLSVLP HDFLRPQQEP YTKQATYSLQ LPQLDVPHDS FSNKYAVALS  60
   61 VWAALIYRVT GDDDIVLYIA NNKILRFNIQ PTWSFNELYS TINNELNKLN SIEANFSFDE 120
  121 LAEKIQSCQD LERTPQLFRL AFLENQDFKL DEFKHHLVDF ALNLDTSNNA HVLNLIYNSL 180
  181 LYSNERVTIV ADQFTQYLTA ALSDPSNCIT KISLITASSK DSLPDPTKNL GWCDFVGCIH 240
  241 DIFQDNAEAF PERTCVVETP TLNSDKSRSF TYRDINRTSN IVAHYLIKTG IKRGDVVMIY 300
  301 SSRGVDLMVC VMGVLKAGAT FSVIDPAYPP ARQTIYLGVA KPRGLIVIRA AGQLDQLVED 360
  361 YINDELEIVS RINSIAIQEN GTIEGGKLDN GEDVLAPYDH YKDTRTGVVV GPDSNPTLSF 420
  421 TSGSEGIPKG VLGRHFSLAY YFNWMSKRFN LTENDKFTML SGIAHDPIQR DMFTPLFLGA 480
  481 QLYVPTQDDI GTPGRLAEWM SKYGCTVTHL TPAMGQLLTA QATTPFPKLH HAFFVGDILT 540
  541 KRDCLRLQTL AENCRIVNMY GTTETQRAVS YFEVKSKNDD PNFLKKLKDV MPAGKGMLNV 600
  601 QLLVVNRNDR TQICGIGEIG EIYVRAGGLA EGYRGLPELN KEKFVNNWFV EKDHWNYLDK 660
  661 DNGEPWRQFW LGPRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTHISQ 720
  721 HPLVRENITL VRKNADNEPT LITFMVPRFD KPDDLSKFQS DVPKEVETDP IVKGLIGYHL 780
  781 LSKDIRTFLK KRLASYAMPS LIVVMDKLPL NPNGKVDKPK LQFPTPKQLN LVAENTVSET 840
  841 DDSQFTNVER EVRDLWLSIL PTKPASVSPD DSFFDLGGHS ILATKMIFTL KKKLQVDLPL 900
  901 GTIFKYPTIK AFAAEIDRIK SSGGSSQGEV VENVTANYAE DAKKLVETLP SSYPSREYFV 960
  961 EPNSAEGKTT INVFVTGVTG FLGSYILADL LGRSPKNYSF KVFAHVRAKD EEAAFARLQK1020
 1021 AGITYGTWNE KFASNIKVVL GDLSKSQFGL SDEKWMDLAN TVDIIIHNGA LVHWVYPYAK1080
 1081 LRDPNVISTI NVMSLAAVGK PKFFDFVSST STLDTEYYFN LSDKLVSEGK PGILESDDLM1140
 1141 NSASGLTGGY GQSKWAAEYI IRRAGERGLR GCIVRPGYVT GASANGSSNT DDFLLRFLKG1200
 1201 SVQLGKIPDI ENSVNMVPVD HVARVVVATS LNPPKENELA VAQVTGHPRI LFKDYLYTLH1260
 1261 DYGYDVEIES YSKWKKSLEA SVIDRNEENA LYPLLHMVLD NLPESTKAPE LDDRNAVASL1320
 1321 KKDTAWTGVD WSNGIGVTPE EVGIYIAFLN KVGFLPPPTH NDKLPLPSIE LTQAQISLVA1380
 1381 SGAGARGSSA AA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LYS2 LYS5
    View Details Krogan NJ, et al. (2006) FES1 LSG1 LYS2
    View Details Gavin AC, et al. (2006) IMD2 LYS2 LYS5 SXM1
    View Details Gavin AC, et al. (2002) ADH1 ECM1 GCN1 HSC82 KAP123 LYS2 LYS5 PSE1 SXM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LYS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] MSA 1.206982 View MSA. No confident structure predictions are available.
    2 View Details [132..213] deduced N/A No confident structure predictions are available.
    3 View Details [214..230]
    [486..697]    		 PSI-BLAST 635.0103 Phenylalanine activating domain of gramicidin synthetase 1
    4 View Details [231..274]
    [423..485]
    [698..843]    		 PSI-BLAST 635.0103 Phenylalanine activating domain of gramicidin synthetase 1
    5 View Details [275..422] PSI-BLAST 635.0103 Phenylalanine activating domain of gramicidin synthetase 1
    6 View Details [844..936] PSI-BLAST 70.440336 Peptidyl carrier protein (PCP), thioester domain
    7 View Details [937..1188] PSI-BLAST 6.045757 VibH
    8 View Details [1189..1392] MSA 1.087943 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • O-acyltransferase activity
    		•  3.20415400376574 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  3.20101546976547 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.5133185343892 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  1.89721072292762 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  1.73532543051487 bayes_pls_golite062009
  • transferase activity
    		•  1.53549002805559 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  1.4571562987488 bayes_pls_golite062009
  • catalytic activity
    		•  1.4057670600405 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  1.33466655894478 bayes_pls_golite062009
  • acyltransferase activity
    		•  1.32890060077614 bayes_pls_golite062009
  • binding
    		•  1.0573980916647 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  0.791271717033212 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.743826754374996 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  0.554321586879044 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  0.534356421723053 bayes_pls_golite062009
  • protein binding
    		•  0.142046790608097 bayes_pls_golite062009
  • succinyltransferase activity
    		•  0.0687075977536176 bayes_pls_golite062009
    2
    Term Confidence Notes
  • fatty acid ligase activity
    		•  3.20885084723265 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  3.09442488073562 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  2.12147420637201 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30923531749766 bayes_pls_golite062009
  • binding
    		•  1.1019187064081 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  0.546415900680738 bayes_pls_golite062009
    3
    Term Confidence Notes
  • acyl carrier activity
    		•  1.48628066075615 bayes_pls_golite062009
  • binding
    		•  1.3440503335733 bayes_pls_golite062009
  • transporter activity
    		•  0.13827434266385 bayes_pls_golite062009
  • catalytic activity
    		•  0.037428828577411 bayes_pls_golite062009
    4
    Term Confidence Notes
  • carnitine O-acyltransferase activity
    		•  3.8017528139322 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  3.7101056995294 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.98258255788559 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  2.37098434941789 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  2.29021577279172 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  2.05222019970921 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  1.82057686950663 bayes_pls_golite062009
  • acyltransferase activity
    		•  1.8182709252044 bayes_pls_golite062009
  • transferase activity
    		•  1.78692523095641 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  1.36884408592523 bayes_pls_golite062009
  • acetyltransferase activity
    		•  1.12787027896966 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  1.1171542351657 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  1.08950177361576 bayes_pls_golite062009
  • binding
    		•  0.999555841397607 bayes_pls_golite062009
  • succinyltransferase activity
    		•  0.542498759931255 bayes_pls_golite062009
  • protein binding
    		•  0.104367069798378 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle