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View Structure Prediction Details

Protein: LYS2
Organism: Saccharomyces cerevisiae
Length: 1392 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS2.

Description E-value Query
Range		 Subject
Range
gi|6563397 - gi|6563397|gb|AAF15891.2|AF204805_1 NosA [Nostoc sp. GSV224]
 0.0 [3..1222] [1294..2478]
gi|9367338 - gi|9367338|emb|CAB97252.1| alpha-aminoadipate reductase [Pichia farinosa]
 0.0 [1..1390] [1..1397]
gi|23506932 - gi|23506932|gb|AAN31950.1| aminoadipate-semialdehyde dehydrogenase; Lys2p [Cloning vector YDp-K]
LYS2 - Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-...
LYS2_YEAST - L-2-aminoadipate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS2 PE=1 SV=...
gi|24711618 - gi|24711618|gb|AAN62753.1| Lys2 [Cloning vector pRS307]
gi|24711625 - gi|24711625|gb|AAN62754.1| Lys2 [Cloning vector pRS317]
gi|24711633 - gi|24711633|gb|AAN62755.1| Lys2 [Cloning vector pRS327]
gi|2358010 - gi|2358010|gb|AAB68951.1| alpha-aminoadipate reductase [Cloning vector pGR8]
 0.0 [1..1379] [1..1379]
LYS2_SCHPO - L-2-aminoadipate reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lys1 PE=1 SV=3
lys1 - aminoadipate-semialdehyde dehydrogenase
 0.0 [4..1388] [15..1416]
LYS2_PENCH - L-2-aminoadipate reductase large subunit OS=Penicillium chrysogenum GN=lys2 PE=3 SV=1
 0.0 [4..1389] [12..1409]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..1223] [1237..2376]
LYS2_CANAX - L-2-aminoadipate reductase large subunit OS=Candida albicans GN=LYS2 PE=3 SV=2
 0.0 [5..1379] [3..1379]
gi|1326063 - gi|1326063|gb|AAC15909.1| alpha-aminoadipate reductase [Schizosaccharomyces pombe]
 0.0 [4..1388] [15..1412]

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Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNEKVWIEK LDNPTLSVLP HDFLRPQQEP YTKQATYSLQ LPQLDVPHDS FSNKYAVALS  60
   61 VWAALIYRVT GDDDIVLYIA NNKILRFNIQ PTWSFNELYS TINNELNKLN SIEANFSFDE 120
  121 LAEKIQSCQD L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
O-acyltransferase activity 3.20415400376574 bayes_pls_golite062009
carnitine O-acyltransferase activity 3.20101546976547 bayes_pls_golite062009
transferase activity, transferring acyl groups 2.5133185343892 bayes_pls_golite062009
O-acetyltransferase activity 1.89721072292762 bayes_pls_golite062009
carnitine O-acetyltransferase activity 1.73532543051487 bayes_pls_golite062009
transferase activity 1.53549002805559 bayes_pls_golite062009
S-acyltransferase activity 1.4571562987488 bayes_pls_golite062009
catalytic activity 1.4057670600405 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 1.33466655894478 bayes_pls_golite062009
acyltransferase activity 1.32890060077614 bayes_pls_golite062009
binding 1.0573980916647 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 0.791271717033212 bayes_pls_golite062009
acetyltransferase activity 0.743826754374996 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 0.554321586879044 bayes_pls_golite062009
S-acetyltransferase activity 0.534356421723053 bayes_pls_golite062009
protein binding 0.142046790608097 bayes_pls_golite062009
succinyltransferase activity 0.0687075977536176 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [132-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERTPQLFRLA FLENQDFKLD EFKHHLVDFA LNLDTSNNAH VLNLIYNSLL YSNERVTIVA  60
   61 DQFTQYLTAA LSDPSNCITK IS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
fatty acid ligase activity 3.20885084723265 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 3.09442488073562 bayes_pls_golite062009
ligase activity 2.49556073715112 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 2.12147420637201 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
transcription regulator activity 1.30923531749766 bayes_pls_golite062009
binding 1.1019187064081 bayes_pls_golite062009
acetate-CoA ligase activity 0.546415900680738 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [214-230] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LITASSKDSL PDPTKNL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [486-697] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQDDIGTPGR LAEWMSKYGC TVTHLTPAMG QLLTAQATTP FPKLHHAFFV GDILTKRDCL  60
   61 RLQTLAENCR IVNMYGTTET QRAVSYFEVK SKNDDPNFLK KLKDVMPAGK GMLNVQLLVV 120
  121 NRNDRTQICG IGEIGEIYVR AGGLAEGYRG LPELNKEKFV NNWFVEKDHW NYLDKDNGEP 180
  181 WRQFWLGPRD RLYRTGDLGR YLPNGDCECC GR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 635.0103
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acyl carrier activity 1.48628066075615 bayes_pls_golite062009
binding 1.3440503335733 bayes_pls_golite062009
transporter activity 0.13827434266385 bayes_pls_golite062009
catalytic activity 0.037428828577411 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [231-274] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWCDFVGCIH DIFQDNAEAF PERTCVVETP TLNSDKSRSF TYRD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [423-485] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEGIPKGVL GRHFSLAYYF NWMSKRFNLT ENDKFTMLSG IAHDPIQRDM FTPLFLGAQL  60
   61 YVP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [698-843] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADDQVKIRGF RIELGEIDTH ISQHPLVREN ITLVRKNADN EPTLITFMVP RFDKPDDLSK  60
   61 FQSDVPKEVE TDPIVKGLIG YHLLSKDIRT FLKKRLASYA MPSLIVVMDK LPLNPNGKVD 120
  121 KPKLQFPTPK QLNLVAENTV SETDDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 635.0103
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
carnitine O-acyltransferase activity 3.8017528139322 bayes_pls_golite062009
O-acyltransferase activity 3.7101056995294 bayes_pls_golite062009
transferase activity, transferring acyl groups 2.98258255788559 bayes_pls_golite062009
O-acetyltransferase activity 2.37098434941789 bayes_pls_golite062009
carnitine O-acetyltransferase activity 2.29021577279172 bayes_pls_golite062009
S-acyltransferase activity 2.05222019970921 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 1.82057686950663 bayes_pls_golite062009
acyltransferase activity 1.8182709252044 bayes_pls_golite062009
transferase activity 1.78692523095641 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 1.36884408592523 bayes_pls_golite062009
acetyltransferase activity 1.12787027896966 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 1.1171542351657 bayes_pls_golite062009
S-acetyltransferase activity 1.08950177361576 bayes_pls_golite062009
binding 0.999555841397607 bayes_pls_golite062009
succinyltransferase activity 0.542498759931255 bayes_pls_golite062009
protein binding 0.104367069798378 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [275-422] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INRTSNIVAH YLIKTGIKRG DVVMIYSSRG VDLMVCVMGV LKAGATFSVI DPAYPPARQT  60
   61 IYLGVAKPRG LIVIRAAGQL DQLVEDYIND ELEIVSRINS IAIQENGTIE GGKLDNGEDV 120
  121 LAPYDHYKDT RTGVVVGPDS NPTLSFTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 635.0103
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [844-936] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFTNVEREVR DLWLSILPTK PASVSPDDSF FDLGGHSILA TKMIFTLKKK LQVDLPLGTI  60
   61 FKYPTIKAFA AEIDRIKSSG GSSQGEVVEN VTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.440336
Match: 1dnyA_
Description: Peptidyl carrier protein (PCP), thioester domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [937-1188] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYAEDAKKLV ETLPSSYPSR EYFVEPNSAE GKTTINVFVT GVTGFLGSYI LADLLGRSPK  60
   61 NYSFKVFAHV RAKDEEAAFA RLQKAGITYG TWNEKFASNI KVVLGDLSKS QFGLSDEKWM 120
  121 DLANTVDIII HNGALVHWVY PYAKLRDPNV ISTINVMSLA AVGKPKFFDF VSSTSTLDTE 180
  181 YYFNLSDKLV SEGKPGILES DDLMNSASGL TGGYGQSKWA AEYIIRRAGE RGLRGCIVRP 240
  241 GYVTGASANG SS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1l5aA_
Description: VibH
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1189-1392] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTDDFLLRFL KGSVQLGKIP DIENSVNMVP VDHVARVVVA TSLNPPKENE LAVAQVTGHP  60
   61 RILFKDYLYT LHDYGYDVEI ESYSKWKKSL EASVIDRNEE NALYPLLHMV LDNLPESTKA 120
  121 PELDDRNAVA SLKKDTAWTG VDWSNGIGVT PEEVGIYIAF LNKVGFLPPP THNDKLPLPS 180
  181 IELTQAQISL VASGAGARGS SAAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle