YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lysine biosynthetic process via aminoadipic acid
Acc: GO:0019878
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.
Synonyms:
  • lysine biosynthesis, aminoadipic pathway
  • lysine biosynthesis, aminoadipic acid pathway
  • lysine anabolism via aminoadipic acid
  • lysine synthesis via aminoadipic acid
  • lysine biosynthetic process, aminoadipic acid pathway
  • lysine biosynthetic process, aminoadipic pathway
  • lysine formation via aminoadipic acid
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019878 - lysine biosynthetic process via aminoadipic acid (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle