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Protein Overview: LYS5

General Information:
Name(s) found: LYS5 / YGL154C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 272 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    Biological Process: protein-cofactor linkage [IDALink to PubMed article]
    lysine biosynthetic process via aminoadipic acid [TASLink to PubMed article]
    Molecular Function: holo-[acyl-carrier-protein] synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKTTEVVSE VSKVAGVRPW AGIFVVEIQE DILADEFTFE ALMRTLPLAS QARILNKKSF  60
   61 HDRCSNLCSQ LLQLFGCSIV TGLNFQELKF DKGSFGKPFL DNNRFLPFSM TIGEQYVAMF 120
  121 LVKCVSTDEY QDVGIDIASP CNYGGREELE LFKEVFSERE FNGLLKASDP CTIFTYLWSL 180
  181 KESYTKFTGT GLNTDLSLID FGAISFFPAE GASMCITLDE VPLIFHSQWF NNEIVTICMP 240
  241 KSISDKINTN RPKLYNISLS TLIDYFIEND GL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LYS2 LYS5
    View Details Gavin AC, et al. (2006) LYS2 LYS5
    View Details Gavin AC, et al. (2002) LYS2 LYS5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 89.522879 4'-Phosphopantetheinyl transferase SFP
    2 View Details [114..272] PSI-BLAST 89.522879 4'-Phosphopantetheinyl transferase SFP


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle