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Protein Overview: VTH2

General Information:
Name(s) found: VTH2 / YJL222W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1549 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: Golgi to vacuole transport [ISSLink to PubMed article]
    Molecular Function: signal sequence binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR AEEDSVEISF  60
   61 DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF YVTDDQGKSW RPLTIPISEK 120
  121 ASNYFCDVTT HPIKKKHLII RCDLLTIKNS GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG 180
  181 HISTARCDFI KSSEDSDLGG NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL 240
  241 VQFKDKVVSR YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ 300
  301 IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ FGYINVAYPG 360
  361 FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL TWTNLKVVDR ENVDLFGCDV 420
  421 TKPERCSLQT HFYDLRNLNP SAGIMMISGI VGDGSAYNWK EEKTFISRDS GLTWRLVHNS 480
  481 TGLYTTGDLG NIIMYIPYRS NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD 540
  541 GSGSKFILTG TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR 600
  601 RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN LIALSDICDK 660
  661 SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS SDKEIVTTEN KFDFEIKFYQ 720
  721 YFDTVADESL VMLNSIGDAY ISHDGGQTIK RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN 780
  781 IFLTHDRGYS FMIAKLPEAR QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK 840
  841 DGGETFTEML DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV 900
  901 FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ DAFTILGSEE 960
  961 GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN TFGYVDFEKV QGLEGIIITN1020
 1021 IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG1080
 1081 YTERKDIRDT YSSGSALGMM FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY1140
 1141 GDHGGVLVLV PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE1200
 1201 AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG HKTEFLRKTD1260
 1261 EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT CKLVKGLSSA NGADICKKEP1320
 1321 DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA PHPCPGKEKA FREKYSINTG AYALVFVTIL1380
 1381 LVIFFVAWFV YDRGIRRNGG FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS1440
 1441 AFQRAKAGTA QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS1500
 1501 EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VTH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..182] MSA 1.005938 View MSA. No confident structure predictions are available.
    2 View Details [183..536] deduced N/A No confident structure predictions are available.
    3 View Details [537..722] MSA 1.007947 View MSA. No confident structure predictions are available.
    4 View Details [723..1398] MSA 7.017001 View MSA. No confident structure predictions are available.
    5 View Details [1399..1549] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • hydrolase activity
    		•  1.41591334858024 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.31047753739918 bayes_pls_golite062009
  • binding
    		•  1.27390601147347 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.24376651680335 bayes_pls_golite062009
  • transporter activity
    		•  1.10239137184953 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.949536954960448 bayes_pls_golite062009
  • clathrin binding
    		•  0.86732360976983 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.781060752903079 bayes_pls_golite062009
  • peptidase activity
    		•  0.685308067211416 bayes_pls_golite062009
  • catalytic activity
    		•  0.660976915716016 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.660409340901077 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.56446678342098 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.486294295028555 bayes_pls_golite062009
  • channel activity
    		•  0.465630241372545 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.465630241372545 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.455589501590218 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.44519612509266 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.437060564683891 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.423920288968837 bayes_pls_golite062009
  • potassium channel activity
    		•  0.423464159542763 bayes_pls_golite062009
  • cation channel activity
    		•  0.406614358442595 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.402494949667906 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.39571309893169 bayes_pls_golite062009
  • ion channel activity
    		•  0.395022246697853 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.387394052239826 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  0.384942719946392 bayes_pls_golite062009
  • protein binding
    		•  0.358634999959382 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.326855275194847 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.300015711462657 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.300015711462657 bayes_pls_golite062009
  • gated channel activity
    		•  0.266124158878986 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  0.258360510712111 bayes_pls_golite062009
  • sugar binding
    		•  0.209524155254648 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.165171466772385 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0429267214247906 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle