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View Structure Prediction Details

Protein: PUS7
Organism: Saccharomyces cerevisiae
Length: 676 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUS7.

Description E-value Query
Range
Subject
Range
PUS7_YEAST - Multisubstrate pseudouridine synthase 7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
PUS7 - Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 50 in 5S rR...
0.0 [1..676] [1..676]
gi|3859671 - gi|3859671|emb|CAA22009.1| hypothetical protein [Candida albicans]
0.0 [18..668] [28..743]
YH2X_SCHPO - Putative pseudouridine synthase C1A4.09 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP...
SPBC1A4.09 - pseudouridine synthase
0.0 [34..664] [43..664]
gi|15620853 - gi|15620853|dbj|BAB67790.1| KIAA1897 protein [Homo sapiens]
0.0 [35..664] [84..632]
CG6745-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6745 (CG6745, FBgn0035901). It is a protein...
gi|220955444, gi... - gi|220955444|gb|ACL90265.1| CG6745-PA [synthetic construct], gi|220945652|gb|ACL85369.1| CG6745-PA [...
0.0 [34..664] [44..679]
CE05155 - Uncharacterized protein family UPF0024 status:Partially_confirmed UniProt:Q17426 protein_id:CAA94883...
0.0 [40..676] [2..558]
TRUD_ARCFU - Probable tRNA pseudouridine synthase D OS=Archaeoglobus fulgidus GN=truD PE=3 SV=1
TRUD_ARCFU - Probable tRNA pseudouridine synthase D OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 43...
0.0 [188..664] [10..411]
TRUD_PYRFU - Probable tRNA pseudouridine synthase D OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 84...
TRUD_PYRFU - Probable tRNA pseudouridine synthase D OS=Pyrococcus furiosus GN=truD PE=3 SV=1
0.0 [188..660] [10..406]
TRUD_PYRHO - Probable tRNA pseudouridine synthase D OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JC...
TRUD_PYRHO - Probable tRNA pseudouridine synthase D OS=Pyrococcus horikoshii GN=truD PE=3 SV=1
0.0 [188..660] [11..407]
TRUD_METTH - Probable tRNA pseudouridine synthase D OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 ...
gi|7482144 - pir||H69070 conserved hypothetical protein MTH1529 - Methanobacterium thermoautotrophicum (strain De...
0.0 [185..662] [4..413]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSEATVK RPLDAHVGPS ENAAKKLKIE QRTQADGIHE ADVGITLFLS PELPGFRGQI  60
   61 KQRYTDFLVN EIDQEGKVIH LTDKGFKMPK KPQRSKEEVN AEKESEAARR QEFNVDP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [118-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELRNQLVEIF GEEDVLKIES VYRTANKMET AKNFEDKSVR TKIHQLLREA FKNELESVTT  60
   61 DTNTFKIARS NRNSRTNKQE KINQTRDANG VENWGYGPSK DFIHFTLHKE NKDTMEAVNV 120
  121 ITKLLRVPSR VIRYAGTKDR RAVTCQRVSI SKIGLDRLNA LNRTLKGMII GNYNFSDASL 180
  181 NLGDLKGNEF VVVIRDVTTG NSEVSLEEIV SNGCKSLSEN GFINYFGMQR FGTFSISTHT 240
  241 IGRELLLSNW KKAAELILSD QDNVLPKSKE ARKIWAETKD AALALKQMPR QCLAENALLY 300
  301 SLSNQRKEED GTYSENAYYT AIMKIPRNLR TMYVHAYQSY VWNSIASKRI ELHGLKLVVG 360
  361 DLVIDTSEKS PLISGIDDED FDEDVREAQF IRAKAVTQED IDSVKYTMED VVLPSPGFDV 420
  421 LYPSNEELKQ LYVDILKADN MDPFNMRRKV RDFSLAGSYR TVIQKPKSLE YRIIHYDDPS 480
  481 QQLVNTDLDI 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 242.0
Match: PF01142
Description: tRNA pseudouridine synthase D (TruD)

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA binding 1.50596754488506 bayes_pls_golite062009
binding 1.49983036545301 bayes_pls_golite062009
nucleic acid binding 1.46911563206977 bayes_pls_golite062009
transcription regulator activity 1.40070005217107 bayes_pls_golite062009
protein binding 0.491459233332405 bayes_pls_golite062009
catalytic activity 0.307971467423079 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.104498084588774 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [608-676]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNNTRAKESG QKYMKAKLDR YMPDKGGEKT AVVLKFQLGT SAYATMALRE LMKLETSRRG  60
   61 DMCDVKENI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle