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Protein Overview: YHM2

General Information:
Name(s) found: YHM2 / YMR241W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 314 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [ISSLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: tricarboxylic acid transport [IDALink to PubMed article]
    mitochondrial genome maintenance [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    tricarboxylate secondary active transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSTTNTAAA NVIEKKPVSF SNILLGACLN LSEVTTLGQP LEVVKTTMAA NRNFTFLESV  60
   61 KHVWSRGGIL GYYQGLIPWA WIEASTKGAV LLFVSAEAEY RFKSLGLNNF ASGILGGVTG 120
  121 GVTQAYLTMG FCTCMKTVEI TRHKSASAGG VPQSSWSVFK NIYKKEGIRG INKGVNAVAI 180
  181 RQMTNWGSRF GLSRLVEDGI RKITGKTNKD DKLNPFEKIG ASALGGGLSA WNQPIEVIRV 240
  241 EMQSKKEDPN RPKNLTVGKT FKYIYQSNGL KGLYRGVTPR IGLGIWQTVF MVGFGDMAKE 300
  301 FVARMTGETP VAKH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADR1 AYR1 BGL2 BZZ1 CBP6 ENP1 FAA1 GAL2 GAR1 GCN3 GSP1 GUF1 HEM15 HRP1 HXT7 KAP104 KTR3 LAS17 MKT1 MRT4 NAB2 NDE1 OAC1 PEP1 PET10 PET9 PHO84 PSD1 RPN1 RPN12 RPT4 RVS167 SLA1 SLC1 SQT1 TFG2 VMA6 VMA8 YDL063C YHM2 YNL035C
    View Details Qiu et al. (2008) ABF2 CTP1 ILV5 MGM101 OAC1 RIM1 RPO41 YHM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YHM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] Pfam 2.60206 Mitochondrial carrier protein No confident structure predictions are available.
    2 View Details [108..206] Pfam 3.769551 Mitochondrial carrier protein No confident structure predictions are available.
    3 View Details [207..314] Pfam 5.79588 Mitochondrial carrier protein No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle