Protein Overview: YHM2

General Information:
Name(s) found:	YHM2 / YMR241W [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome [SGD]
Organism:	Saccharomyces cerevisiae
Length:	314 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [ISS] mitochondrial nucleoid [IDA]
Biological Process:	tricarboxylic acid transport [IDA] mitochondrial genome maintenance [IGI][IMP]
Molecular Function:	DNA binding [IDA] tricarboxylate secondary active transmembrane transporter activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSTTNTAAA NVIEKKPVSF SNILLGACLN LSEVTTLGQP LEVVKTTMAA NRNFTFLESV  60
   61 KHVWSRGGIL GYYQGLIPWA WIEASTKGAV LLFVSAEAEY RFKSLGLNNF ASGILGGVTG 120
  121 GVTQAYLTMG FCTCMKTVEI TRHKSASAGG VPQSSWSVFK NIYKKEGIRG INKGVNAVAI 180
  181 RQMTNWGSRF GLSRLVEDGI RKITGKTNKD DKLNPFEKIG ASALGGGLSA WNQPIEVIRV 240
  241 EMQSKKEDPN RPKNLTVGKT FKYIYQSNGL KGLYRGVTPR IGLGIWQTVF MVGFGDMAKE 300
  301 FVARMTGETP VAKH

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ADR1 AYR1 BGL2 BZZ1 CBP6 ENP1 FAA1 GAL2 GAR1 GCN3 GSP1 GUF1 HEM15 HRP1 HXT7 KAP104 KTR3 LAS17 MKT1 MRT4 NAB2 NDE1 OAC1 PEP1 PET10 PET9 PHO84 PSD1 RPN1 RPN12 RPT4 RVS167 SLA1 SLC1 SQT1 TFG2 VMA6 VMA8 YDL063C YHM2 YNL035C
View Details	Qiu et al. (2008)		ABF2 CTP1 ILV5 MGM101 OAC1 RIM1 RPO41 YHM2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	RLF2	identification data - first search in cascade	Green EM, et al (2005)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SEC17	YHM2	1	Unpublished Fields Lab Data
View Screen	CHL4	YHM2	1	Unpublished Fields Lab Data
View Screen	SPT23	YHM2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YHM2	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..107]	Pfam	2.60206	Mitochondrial carrier protein No confident structure predictions are available.
2	View Details	[108..206]	Pfam	3.769551	Mitochondrial carrier protein No confident structure predictions are available.
3	View Details	[207..314]	Pfam	5.79588	Mitochondrial carrier protein No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.47

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2