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Protein Overview: RMA1

General Information:
Name(s) found: RMA1 / YKL132C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDISGRQTL PRINRLLEHV GNPQDSLSIL HIAGTNGKET VSKFLTSILQ HPGQQRQRVL  60
   61 IGRYTTSSLL NAKEEDISIN NEAISLIEYS RIEKELIEAD SSLKLQCNNL ELLTSVALVY 120
  121 FAKKNCQWCI IETGLAGKQD PGSIIAGQSR VCCAITNVGI SDEAFLCKFL SQITESSTNK 180
  181 AIFLLDGSND EFVRNTITKR CHDVGCPLEI TDPSLRDYNV HTDTWGTLEV RLPYSEEEYQ 240
  241 IFNLRVAIAV LDFLSKEKKV CISKDQLSQG LISVDWPRSL HRLDYCYEST SGKKIALLLD 300
  301 NANNAKAARN LACHLRTTYG DTPLTFVIAI TTGKKVSPLL DPLIRPQDYV IVTRFGSVVG 360
  361 MPWIQSLEPV NLLAFIKNRY TRNVNMQPDL QSVWTFLETS GLKTIVPVIV CGSLYICKEL 420
  421 LRLHNCHLPV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..276] PSI-BLAST 184.9897 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
    2 View Details [277..430] PSI-BLAST 184.9897 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acid-amino acid ligase activity
    		•  4.03401034724886 bayes_pls_golite062009
  • tetrahydrofolylpolyglutamate synthase activity
    		•  3.94486215528378 bayes_pls_golite062009
  • ligase activity
    		•  3.80574681739772 bayes_pls_golite062009
  • catalytic activity
    		•  2.66037860982128 bayes_pls_golite062009
  • dihydrofolate synthase activity
    		•  2.50201834836027 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.96801058335544 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle