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Protein Overview: RGA2

General Information:
Name(s) found: RGA2 / YDR379W [SGD]
Description(s) found:
Found 27 descriptions.
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  • GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1009 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: budding cell isotropic bud growth [ISSLink to PubMed article]
    small GTPase mediated signal transduction [ISSLink to PubMed article]
    pseudohyphal growth [ISSLink to PubMed article]
    actin filament organization [ISSLink to PubMed article]
    invasive growth in response to glucose limitation [ISSLink to PubMed article]
    budding cell apical bud growth [ISSLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [TASLink to PubMed article]
    Molecular Function: Rho GTPase activator activity [ISSLink to PubMed article]
    signal transducer activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD SDFLVLDIGT  60
   61 LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR CSNRIKNLKY AKTKRGLCCM 120
  121 DCHEKLLRKK QLLLENQTKN SSKEDFPIKL PERSVKRPLS PTRINGKSDV STNNTAISKN 180
  181 LVSSNEDQQL TPQVLVSQER DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD 240
  241 SNSIEEQSLV DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD 300
  301 KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL ALTLSEATKE 360
  361 NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR LSDNGSFSRP QTADNLLPHK 420
  421 KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS EMLDPKHPHH STSIQESDTH SGWGVSSTHT 480
  481 NIRKSKAKKN PVSRGQSDST IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN 540
  541 RRINGSFTSS SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD 600
  601 STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR LAKERLLNDV 660
  661 DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK GSISNASPKP RFWKIFSSAK 720
  721 DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP 780
  781 DGSHLYGSSL QARCAYEKST VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE 840
  841 FAQNNSLHSD TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL 900
  901 IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI GKVRRCSERN 960
  961 LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG NYRDIFKQA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C
    View Details Gavin AC, et al. (2002) BEM2 PPH3 PSY2 PSY4 RGA2 SPT5 TDH3 TRM3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RGA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] PSI-BLAST 38.228787 Cysteine-rich (intestinal) protein, CRP, CRIP
    2 View Details [71..149] PSI-BLAST 38.228787 Cysteine-rich (intestinal) protein, CRP, CRIP
    3 View Details [150..225] PSI-BLAST 10.154902 Insulin gene enhancer protein isl-1
    4 View Details [226..580] MSA 3.138996 View MSA. No confident structure predictions are available.
    5 View Details [581..725] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [726..879] PSI-BLAST 193.30103 p50 RhoGAP domain
    7 View Details [880..1009] PSI-BLAST 193.30103 p50 RhoGAP domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.53476602786095 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.31497455728997 bayes_pls_golite062009
  • actin binding
    		•  2.12981903473593 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.49086416765132 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • DNA binding
    		•  1.27439935466101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.07089120477749 bayes_pls_golite062009
  • receptor activity
    		•  1.05205471090697 bayes_pls_golite062009
  • actin filament binding
    		•  0.924007456077191 bayes_pls_golite062009
  • transcription factor activity
    		•  0.73645718855149 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.00178877672043032 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.61981913117676 bayes_pls_golite062009
  • binding
    		•  2.59846425523141 bayes_pls_golite062009
  • DNA binding
    		•  2.33064128336595 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11285031339066 bayes_pls_golite062009
  • actin binding
    		•  2.03209305727522 bayes_pls_golite062009
  • transcription factor activity
    		•  1.89582335878776 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • actin filament binding
    		•  0.81690252782831 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.78609133101699 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42661918396987 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.24744905965946 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.156446003827888 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0526130265453202 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.42802398019084 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.29568423512865 bayes_pls_golite062009
  • actin binding
    		•  3.13452682535963 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.30141000926447 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • motor activity
    		•  2.04743766323523 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • diacylglycerol binding
    		•  1.75824354852133 bayes_pls_golite062009
  • tubulin binding
    		•  1.56332747753627 bayes_pls_golite062009
  • actin filament binding
    		•  1.49148700086734 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.07737775291413 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.847021935833721 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • microtubule binding
    		•  0.648232426961013 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.36751853312336 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.348246993470003 bayes_pls_golite062009
  • Rho GTPase binding
    		•  0.33949271618205 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle