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Protein Overview: CWH41

General Information:
Name(s) found: CWH41 / YGL027C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 833 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article][ISSLink to PubMed article]
    protein amino acid N-linked glycosylation [IMPLink to PubMed article]
    Molecular Function: mannosyl-oligosaccharide glucosidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLISKSKMFK TFWILTSIVL LASATVDISK LQEFEEYQKF TNESLLWAPY RSNCYFGMRP  60
   61 RYVHESPLIM GIMWFNSLSQ DGLHSLRHFA TPQDKLQKYG WEVYDPRIGG KEVFIDEKNN 120
  121 LNLTVYFVKS KNGENWSVRV QGEPLDPKRP STASVVLYFS QNGGEIDGKS SLAMIGHDGP 180
  181 NDMKFFGYSK ELGEYHLTVK DNFGHYFKNP EYETMEVAPG SDCSKTSHLS LQIPDKEVWK 240
  241 ARDVFQSLVS DSIRDILEKE ETKQRPADLI PSVLTIRNLY NFNPGNFHYI QKTFDLTKKD 300
  301 GFQFDITYNK LGTTQSISTR EQVTELITWS LNEINARFDK QFSFGEGPDS IESVEVKRRF 360
  361 ALETLSNLLG GIGYFYGNQL IDRETEFDES QFTEIKLLNA KEEGPFELFT SVPSRGFFPR 420
  421 GFYWDEGFHL LQIMEYDFDL AFEILASWFE MIEDDSGWIA REIILGNEAR SKVPQEFQVQ 480
  481 NPNIANPPTL LLAFSEMLSR AIENIGDFNS DSYHQVMFNS RTAKFMTNNL EANPGLLTEY 540
  541 AKKIYPKLLK HYNWFRKSQT GLIDEYEEIL EDEGIWDKIH KNEVYRWVGR TFTHCLPSGM 600
  601 DDYPRAQPPD VAELNVDALA WVGVMTRSMK QIAHVLKLTQ DEQRYAQIEQ EVVENLDLLH 660
  661 WSENDNCYCD ISIDPEDDEI REFVCHEGYV SVLPFALKLI PKNSPKLEKV VALMSDPEKI 720
  721 FSDYGLLSLS RQDDYFGKDE NYWRGPIWMN INYLCLDAMR YYYPEVILDV AGEASNAKKL 780
  781 YQSLKINLSN NIYKVWEEQG YCYENYSPID GHGTGAEHFT GWTALVVNIL GRF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..833] Pfam 1000.0 Mannosyl oligosaccharide glucosidase No confident structure predictions are available.
    2 View Details [182..275] deduced N/A No confident structure predictions are available.
    3 View Details [276..833] PSI-BLAST 101.0 No description for 2jf4A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  3.49882811932206 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.13521240810366 bayes_pls_golite062009
  • catalytic activity
    		•  1.16285856935495 bayes_pls_golite062009
  • binding
    		•  1.06330183651166 bayes_pls_golite062009
  • trehalase activity
    		•  0.389375574251869 bayes_pls_golite062009
  • protein binding
    		•  0.18984948020481 bayes_pls_golite062009
  • alpha,alpha-trehalase activity
    		•  0.17719034423607 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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