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Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: tetrahydrofolylpolyglutamate synthase activity
Acc: GO:0004326
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
Synonyms:
  • formyltetrahydropteroyldiglutamate synthetase activity
  • tetrahydrofolate synthase activity
  • folate polyglutamate synthetase activity
  • folylpolyglutamyl synthetase activity
  • N(10)-formyltetrahydropteroyldiglutamate synthetase activity
  • tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
  • tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
  • tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
  • folylpoly(gamma-glutamate) synthase activity
  • folylpolyglutamate synthase activity
  • folylpolyglutamate synthetase activity
  • N10-formyltetrahydropteroyldiglutamate synthetase activity
  • folylpoly-gamma-glutamate synthase activity
  • FPGS activity
  • folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
Proteins in PDR annotated with:
   This term: 31 [Search]
   Term or descendants: 31 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004326 - tetrahydrofolylpolyglutamate synthase activity (interactive image map)

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