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Protein Overview: DOP1

General Information:
Name(s) found: DOP1 / YDR141C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1698 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cell morphogenesis [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLKPLTI DSNNKQLDSK QKKFRANVER ALERFDSVTE WADYIASLGT LLKALQSWSP  60
   61 KFQNVRYYVP SPYQVSRRLT SSLSPALPAG VHQKTLEVYT YIFEHIGLET LATECNIWIP 120
  121 GILPLMTYAS MSVRSHLIEL YDNYILLLPQ TTLRLLIRPL ISSLLPGIDD ESNDFLPLTL 180
  181 KLIETLQENL DDDSLFWQTL FLVMTANKGR RLGGLTWLTR KFPSLNAVPH LVNKIKMEAE 240
  241 ENPSETETND SHLDRKKRKE EAFKVLLPAA KDLVTPEPGL LIRCLVGCLE DENDILIKRS 300
  301 VLDLLLQRLR LDSPVLNVLI TSEDKKLLIM SCCRTTLSKD MSLNRRIWNW LLGPTAGGML 360
  361 NNNGGNSMEY TTSVKSANEE SNVYFTKYGL SALLEGLSDL LSEEESVLTA FRISMAVMDR 420
  421 WEIGSLVIPE LFIPLLYSSE KFKQNEQIMK TARTFFDNTE TNIIWGKLFQ ELEDIKNLKI 480
  481 LDFVLTNFNI GNDEEIIVRH LPLILLTLLA LPSNDKDFDN IYKLQKFSLY NKLLNYIPER 540
  541 ALLPLSHSKL KHDDEVSCEE LLAKIRGFYT NVSNPSSILE KENIAERLPP FTTEDLTFLI 600
  601 ADLIQKKLLS SLWDLENINE SSKLFIAIFE KIPESEELKG RSHISWSDKK ITQSIFEAIP 660
  661 RLCESNNDAK SEEIVGIVEI FGNYLYSRME FIESMKLLKV VMMAVWKSLK DPRHQILGVK 720
  721 NLKTLNRFIP SKFIESALVY TFVEEEDISE RLSVLDLLWT QLDSDSNLIR RPLELILGEL 780
  781 FDDQNPFYLT VSKWILSILN SGSASRLFYI LTDNILKVNR LEKERLDERD DLDMLTYEFQ 840
  841 MLAYVLKTNN GRTRKVFSTE LTSIKSSTIW KNEDVSTYKS LLLVTLMRFL NIKSNTHAKS 900
  901 IRSALILLDI LLDGTEQNFK DIVIFLLQMS SKYIAEEGIE PELIAVSLLD IVSKVLRLSH 960
  961 DNGIKLDIFD DNAAHLKYID FLVTSVSNMK SPLIVTAYVK LLSESIVYFE NSIFRMILPL1020
 1021 SASLVQCVQR LFLLEKREGG YYQPIALLLG GLEELLEISH GYLVTEEREG YFSGSNLKGD1080
 1081 FIQSVVSNVF SSDSSNEESK IQGERDVILQ SFRQVISCCL DIWYWAHNIS CKSNDDSSLD1140
 1141 ATNHNSYKFK FRSKKLLETL FLLEPLELLE NLISIRSDNT TVTLVHVLDG NKPAITIPHL1200
 1201 LYGVIIRYNR TASVKFSNRD GSRSSTTKLT KGEPSMLKRL SGESIIAFLF NYVDSVENSA1260
 1261 MEEFYGDFLL FFREVATNYN LYSDVSLSIL KLVALISGKV SKTQFGEQKR VRREISDVFF1320
 1321 KYLPNAFINF TNLYRGHPDS FKDLEFVVWR VQYIVNDQIG GDKFNTTLAT IVNQCLTPYI1380
 1381 KPKSEKTIPG YVLELAAVVS HLGSKVKSWR LLIAELFQND KKLSVIGSDQ TWEKIIYEWS1440
 1441 IYPENKSKIL NDLLLEIGSK RSSVTPTLIT FNLGSDSEVE YKCQNLLKIS YLLMVSPNDA1500
 1501 YLLHFSSLIS CIFHYLVSKD IKLKGSCWIL LRVLLLRFSE SHFNDYWSMI SYCLQTNLQE1560
 1561 FYESLQIQSE VDPQTILQVC KTLDLLLLLN MEGFTSTNEW IFVIDTINCV YKTNSFVALV1620
 1621 DEIAEFKDYE ITKTDDLELP TTLKDGLPLL RGIHKIERHT QLRSFFQNLS YLHYEKVYGL1680
 1681 GSVDLYGCGE DLKKDILS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DOP1 MON2
    View Details Gavin AC, et al. (2006) DOP1 MON2
    View Details Ho Y, et al. (2002) ADR1 BEM3 DOP1 ECM29 KAP122 MET18 RPA135 RPA190 RPC40 RPO31 SRY1 YER138C YIL055C YTA7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DOP1 Huh WK, et al. (2003)
    View Data DOP1 and COP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] MSA 2.009951 View MSA. No confident structure predictions are available.
    2 View Details [236..892] deduced N/A No confident structure predictions are available.
    3 View Details [893..1698] MSA 4.009001 View MSA. No confident structure predictions are available.
    4 View Details [547..668] deduced N/A No confident structure predictions are available.
    5 View Details [669..892] deduced N/A No confident structure predictions are available.
    6 View Details [893..962] deduced N/A No confident structure predictions are available.
    7 View Details [963..1175] deduced N/A No confident structure predictions are available.
    8 View Details [1176..1324] deduced N/A No confident structure predictions are available.
    9 View Details [1325..1541] deduced N/A No confident structure predictions are available.
    10 View Details [1542..1698] MSA 3.035979 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle