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View Structure Prediction Details

Protein: ECM29
Organism: Saccharomyces cerevisiae
Length: 1868 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM29.

Description E-value Query
Range
Subject
Range
ECM29 - Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, ...
ECM29_YEAST - Proteasome component ECM29 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM29 PE=1 SV...
0.0 [1..1868] [1..1868]
CE00639 - status:Partially_confirmed UniProt:Q18983 protein_id:CAA84693.1
0.0 [14..1719] [7..1663]
gi|2224677 - gi|2224677|dbj|BAA20823.1| KIAA0368 [Homo sapiens]
0.0 [418..1694] [9..1267]
gi|5042415, gi|2... - gi|5042415|gb|AAD38254.1|AC006193_10 similar to translational activator [Arabidopsis thaliana], pir|...
0.0 [421..1753] [1246..2611]
SPAC18G6.05c - translation elongation regulator Gcn1
GCN1_SCHPO - eIF-2-alpha kinase activator gcn1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gcn1 PE=...
0.0 [442..1678] [1230..2449]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISSDEAKE KQLVEKAELR LAIADSPQKF ETNLQTFLPP LLLKLASPHA SVRTAVFSAL  60
   61 KNLISRINTL PQVQLPVRAL IVQAKEPNLA AQQDSTNVRL YSLLLASKGI DRLSLQDRQQ 120
  121 LLPLVVSNIS CLTGTVAARM FHILLKLILE W

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity 2.62777210765927 bayes_pls_golite062009
binding 2.26699794423696 bayes_pls_golite062009
nucleic acid binding 0.954891553462304 bayes_pls_golite062009
protein binding 0.867374463164997 bayes_pls_golite062009
DNA binding 0.0652553830451623 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [152-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPQESSHEQ EEFVQFLQLD NDGFSFLMRQ FTRFFLLVPS KQVQVSQQPL SRGYTCPGLS  60
   61 LTDVAFFTYD AGVTFNKEQL NKFKKAIFQF VCRGMAATQT IEQSPRMIEL MEFLCVVSTD 120
  121 STNLSDDAAQ FMKRFPMPYE NEEFITFLQT LYIGNTANGR PPVKAILQEK ILSILNRSHF 180
  181 ATTKAECISL ICSIGLHSSE YKLRSLTLSF IRHVAKLNYK NLNPASSSPS STDFSTCIVS 240
  241 LIRNNLHAEG WPKLQLGPQT PAFNTAILQR QLQYETLGDI LKRDFELVSD LSYIEFLFES 300
  301 LKNDLPQFRS SIQESLLSLV GHLSILPQQS KLKLKNLLRK NLSIDEQQRE DNNDAVNSIM 360
  361 ALKFVSIKFT NAAF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity 2.5894939457048 bayes_pls_golite062009
binding 2.37294644142029 bayes_pls_golite062009
nucleic acid binding 1.00618489031368 bayes_pls_golite062009
protein binding 0.992946510849437 bayes_pls_golite062009
DNA binding 0.0559585284546991 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [526-878]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFHDPEARLF NIWGTVRTNR FDIIEESFKG LQPFWFRVNN ASINTSATVK TSDLLGSHLS  60
   61 ETEFPPFREF LQVLIDQLDS EAASITRKSL NNAVRFSKQC LISNAIYGKK TMVIQDEDWS 120
  121 VRIDKALELD DTVVSRVNEM VQGMNDDIFI RYLTLLSNEF TATNSKGEQI AIFPYQDPIF 180
  181 GSVLLTLLNF VSNNVLRRLE ILVPDLYHLV IMKFQSLSDN DLAVCATIIG IISTAIADST 240
  241 HVKRITKIAQ SQTMAETYVA SYVVPRLYLK DQTNHIESDS ILNLLNILTT HLSHPGTNKD 300
  301 MILKLVCQVT KFGLLLQVSA QERKDFLKKV MDTIQDKLIN DVTAIQTWSY LSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [879-1022]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSTDLENSSL FQEKLLETNV SKQNDFLFSV GESLSVVAGK WSSKYLIKQI DIPNFNVEIM  60
   61 QQKFPATNVT TILDEIFSGC DSTKPSLRKA SCIWLLSYIQ YLGHLPEVSS KCNDIHLRFM 120
  121 RFLADRDEFI QDSAARGLSL VYEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.0
Match: 1f59A_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1023-1153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSDLKESMV KGLLKSFTES TAGSASTSAT GISGSVSEET ELFEPGVLNT GDGSISTYKD  60
   61 ILNLASEVGD PALVYKFMSL AKSSALWSSR KGIAFGLGAI MSKSSLEELL LKDQQTAKKL 120
  121 IPKLYRYRFD P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1154-1629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQAVSRSMTD IWNTLIPESS LTISLYFNDI LDELLCGMAN KEWRVREAST SALLQLIQSQ  60
   61 PQEKFSEKML KIWTMAFRTM DDIKDSVREV GTKFTTVLAK ILARSIDVEK GVNPTKSKEI 120
  121 LDNILPFLWG PHGLNSDAEE VRNFALTTLI DLVKHSPGAI KPFTPKLIYD FITLFSSIEP 180
  181 QVINYLALNA ANYNIDANVI DTQRKNGVTN SPLFQTIEKL INNSDDCMME EIINVVIKAS 240
  241 RKSVGLPSKV ASSLVIIILV KRYSIEMKPY SGKLLKVCLT MFEDRNESVN IAFAISMGYL 300
  301 FKVSALDKCI KYSEKLITKY FEPTSTENNK KVVGTAIDSI LNYAKSEFDN VASVFMPLIF 360
  361 IACNDEDKDL ETLYNKIWTE ASSSGAGTVK LYLPEILNVL CVNIKSNDFS IRKTCAKSVI 420
  421 QLCGGINDSI PYPQIVKLFD ISREALSGRS WDGKEHIVAA LVSLTEKFSQ TVADNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1630-1868]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLQESINHVM YTEVSRKSMK YVKKILPLYA RYINVNPQEE TITFLIEKAK EMIRLLGSES  60
   61 DDSEGSIKQT SDESTIKRIK PNTEITQKSS KENIENEEYV INLLKVSVDI CNNSKSRYPM 120
  121 NLLEFIIDEI AYLFHNDRII HTWRTQLAAS EIGISIVGRF STISSADFIQ NVGRLWDQTF 180
  181 PINCNKETIE NVKLQMIKFG GLIIQKIPSL QNNIEENLRL LNSIDSTSRI ELELKNIGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle