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Protein Overview: FAR1

General Information:
Name(s) found: FAR1 / YJL157C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 830 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    membrane [IDALink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: cell cycle arrest [IMPLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGILink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase inhibitor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTPTRVSFE KKIHTPPSGD RDAERSPPKK FLRGLSGKVF RKTPEFKKQQ MPTFGYIEES  60
   61 QFTPNLGLMM SKRGNIPKPL NLSKPISPPP SLKKTAGSVA SGFSKTGQLS ALQSPVNITS 120
  121 SNKYNIKATN LTTSLLRESI SDSTTMCDTL SDINLTVMDE DYRIDGDSYY EEDSPTFMIS 180
  181 LERNIKKCNS QFSPKRYIGE KCLICEESIS STFTGEKVVE STCSHTSHYN CYLMLFETLY 240
  241 FQGKFPECKI CGEVSKPKDK DIVPEMVSKL LTGAGAHDDG PSSNMQQQWI DLKTARSFTG 300
  301 EFPQFTPQEQ LIRTADISCD GFRTPRLSNS NQFEAVSYLD SPFLNSPFVN KMATTDPFDL 360
  361 SDDEKLDCDD EIDESAAEVW FSKTGGEHVM VSVKFQEMRT SDDLGVLQDV NHVDHEELEE 420
  421 REKEWKKKID QYIETNVDKD SEFGSLILFD KLMYSDDGEQ WVDNNLVILF SKFLVLFDFE 480
  481 EMKILGKIPR DQFYQVIKFN EDVLLCSLKS TNIPEIYLRF NENCEKWLLP KWKYCLENSS 540
  541 LETLPLSEIV STVKELSHVN IIGALGAPPD VISAQSHDSR LPWKRLHSDT PLKLIVCLNL 600
  601 SHADGELYRK RVLKSVHQIL DGLNTDDLLG IVVVGRDGSG VVGPFGTFIG MINKNWDGWT 660
  661 TFLDNLEVVN PNVFRDEKQQ YKVTLQTCER LASTSAYVDT DDHIATGYAK QILVLNGSDV 720
  721 VDIEHDQKLK KAFDQLSYHW RYEISQRRMT PLNASIKQFL EELHTKRYLD VTLRLPQATF 780
  781 EQVYLGDMAA GEQKTRLIMD EHPHSSLIEI EYFDLVKQQR IHQTLEVPNL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CAR2 CLU1 COP1 DMA2 DUN1 FAR1 GPD1 GPD2 LSP1 MDM30 PDC6 PIL1 RAD1 RPT3 SAW1 SEC6 SEN1 SRP1 SSK2 STE20 UBI4 UBP15 YHR033W
    View Details Qiu et al. (2008) CDC24 FAR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC24 FAR1 2 Drees BL, et al. (2001)
    View Screen BEM1 FAR1 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FAR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] deduced N/A No confident structure predictions are available.
    2 View Details [175..521] MSA 1.002915 View MSA. No confident structure predictions are available.
    3 View Details [522..830] deduced N/A No confident structure predictions are available.
    4 View Details [458..566] deduced N/A No confident structure predictions are available.
    5 View Details [567..830] FFAS03 2.0 Crystal structure of B. anthracis Protective Antigen complexed with human Anthrax toxin receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.70912934275371 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.28868969987463 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91032952208441 bayes_pls_golite062009
  • DNA binding
    		•  1.68057595006321 bayes_pls_golite062009
  • protein binding
    		•  1.48593945455888 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.29842157714791 bayes_pls_golite062009
  • ligase activity
    		•  1.14926486052218 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.11631628759929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.94885431027576 bayes_pls_golite062009
  • transcription factor binding
    		•  0.910854221571241 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.405909265264862 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.185296082082721 bayes_pls_golite062009
  • catalytic activity
    		•  0.168711389690753 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0236792532316743 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.68315152218267 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.69563050637199 bayes_pls_golite062009
  • DNA binding
    		•  1.5974492205508 bayes_pls_golite062009
  • protein binding
    		•  1.42792331963866 bayes_pls_golite062009
  • protein complex binding
    		•  1.2199981922324 bayes_pls_golite062009
  • receptor binding
    		•  1.00252885030613 bayes_pls_golite062009
  • receptor activity
    		•  0.898641472317111 bayes_pls_golite062009
  • signal transducer activity
    		•  0.670518084602683 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.670518084602683 bayes_pls_golite062009
  • structural molecule activity
    		•  0.344350079952659 bayes_pls_golite062009
  • peptide binding
    		•  0.0829901132484674 bayes_pls_golite062009
  • catalytic activity
    		•  0.0380261580236634 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle