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Protein Overview: ESS1

General Information:
Name(s) found: ESS1 / YJR017C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 170 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    mRNA processing [IMPLink to PubMed article]
    termination of RNA polymerase II transcription [IMPLink to PubMed article]
    negative regulation of phosphorylation [IDALink to PubMed article]
    Molecular Function: transcription elongation regulator activity [IGILink to PubMed article]
    peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSDVASRTG LPTPWTVRYS KSKKREYFFN PETKHSQWEE PEGTNKDQLH KHLRDHPVRV  60
   61 RCLHILIKHK DSRRPASHRS ENITISKQDA TDELKTLITR LDDDSKTNSF EALAKERSDC 120
  121 SSYKRGGDLG WFGRGEMQPS FEDAAFQLKV GEVSDIVESG SGVHVIKRVG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALG3 BUD27 CBF2 DST1 ESS1 IWR1 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 TAF14 TFG1 TFG2 YBL059W YBR259W YPL225W
    View Details Ho Y, et al. (2002) BCY1 CAR2 CPR6 ESS1 HEF3 HSP104 HXT6 MDN1 PUP2 RPB3 RPN1 RPO21 SPT5 TFG1 TOM1 UTP22 YHR033W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ESS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 34.522879 Mitotic rotamase PIN1; Mitotic rotamase PIN1, domain 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.64797495383748 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription activator activity
    		•  2.28375305944516 bayes_pls_golite062009
  • transcription factor binding
    		•  2.18630749239417 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.07432061489599 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.02433252968502 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.81795522051605 bayes_pls_golite062009
  • macrolide binding
    		•  1.71427500929512 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • FK506 binding
    		•  1.49236065710546 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.911388717587011 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.75548957875935 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • SMAD binding
    		•  0.325741923624893 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • protein binding
    		•  0.0371998661994551 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle