Protein Overview: SWM1

General Information:
Name(s) found:	SWM1 / YDR260C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	170 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] anaphase-promoting complex [IDA]
Biological Process:	regulation of mitotic metaphase/anaphase transition [IMP] anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IPI] ascospore wall assembly [IMP] protein ubiquitination [IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSYRDSY FQYRHLPAPH HILYAEWNQD ILALPDEVAN ITMAMKDNTR TDAEEGRAPQ  60
   61 DGERNSNVRE SAQGKALMTS EQNSNRYWNS FHDEDDWNLF NGMELESNGV VTFAGQAFDH 120
  121 SLNGGTNSRN DGANEPRKET ITGSIFDRRI TQLAYARNNG WHELALPQSR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ARO1 ARP2 CDC23 CPA1 HYP2 PRB1 PRP28 RNQ1 SWM1 TCB3 URA7
View Details	Qiu et al. (2008)		APC11 APC2 CDC16 CDC23 CDC26 DOC1 MND2 SWM1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC23	SWM1	2	Unpublished Fields Lab Data
View Screen	NSE5	SWM1	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..170]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2