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Protein Overview: DOC1

General Information:
Name(s) found: DOC1 / YGL240W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 250 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    Molecular Function: enzyme regulator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPIGINKVL DHLAPSELIK PVKSCHNKPS VLVLDDRIVD AATKDLYVNG FQEEIQYQNP  60
   61 TPENLQHMFH QGIEILDSAR MINVTHLALW KPSSFKLGNP VDFALDDNYD TFWQSDGGQP 120
  121 HQLDIMFSKR MDICVMAIFF SMIADESYAP SLVKVYAGHS PSDARFYKML EVRNVNGWVA 180
  181 LRFLDNREDD QLLKCQFIRL LFPVNHENGK DTHLRGIRLY VPSNEPHQDT HEWAQTLPET 240
  241 NNVFQDAILR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APC2 APC4 DOC1
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1 SWM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DOC1 SNA4 2 Unpublished Fields Lab Data
    View Screen DOC1 ATG7 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DOC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..250] PSI-BLAST 72.69897 APC10/DOC1 subunit of the anaphase-promoting complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  8.2536490347155 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.94028983948676 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.95223443027718 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.78575924847122 bayes_pls_golite062009
  • ligase activity
    		•  2.23368019733876 bayes_pls_golite062009
  • binding
    		•  2.16986209889839 bayes_pls_golite062009
  • protein binding
    		•  1.06560945718583 bayes_pls_golite062009
  • hydrolase activity
    		•  0.690426836233441 bayes_pls_golite062009
  • protein kinase activity
    		•  0.615340190084121 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.533285414042183 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.289551445698612 bayes_pls_golite062009
  • kinase activity
    		•  0.197678597934074 bayes_pls_golite062009
  • DNA binding
    		•  0.186569142108209 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.185939854910418 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle