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Protein Overview: APC11

General Information:
Name(s) found: APC11 / YDL008W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 165 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article][TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKINEVHS VFAWSWHIPS TSDEDAANND PIGNDEDEDV CGICRASYNG TCPSCKFPGD  60
   61 QCPLVIGLCH HNFHDHCIYR WLDTPTSKGL CPMCRQTFQL QKGLAINDAH VQKFVEIVSR 120
  121 RREEMIEEGV AEEFVDFDEP IRQNTDNPIG RQQVDTILDE DFLLR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC11 SAP1
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1 MND2 SWM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APC11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] PSI-BLAST 71.68867 RIGG-box protein 1 (RBX1) of SCF ubiquitin ligase complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  10.2497392096259 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  10.0460587929138 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.99384576623969 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.6988425139962 bayes_pls_golite062009
  • ligase activity
    		•  3.92677358871643 bayes_pls_golite062009
  • binding
    		•  2.58862749918018 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  2.41658628840288 bayes_pls_golite062009
  • protein binding
    		•  1.49775478023418 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.708499177773075 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.681643203460463 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.392372133643049 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • DNA binding
    		•  0.227671243150662 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • enzyme binding
    		•  0.104373352314595 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle