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Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ubiquitin thiolesterase activity
Acc: GO:0004221
Aspect: Molecular Function
Desc: Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
Synonyms:
  • ubiquitin thioesterase activity
  • ubiquitin carboxy-terminal esterase activity
  • ubiquitin-C-terminal-thioester hydrolase activity
  • GO:0008577
  • ubiquitin carboxy-terminal hydrolase activity
  • ubiquitinyl hydrolase 1 activity
  • ubiquitin C-terminal hydrolase activity
Proteins in PDR annotated with:
   This term: 339 [Search]
   Term or descendants: 339 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004221 - ubiquitin thiolesterase activity (interactive image map)
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