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Protein Overview: APC4

General Information:
Name(s) found: APC4 / YDR118W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 652 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPINDYFI DYNPLFPIFA TRIAKGLAIY RVSDHARLAV IPIRNINLVA NYDWDTTTGK  60
   61 FLSIFFKDGT IRIHDIFKDG RLVSFLRIPS TKISKGIWDR IPLRYEPNNR DFACNIIDDL 120
  121 PKLIRFVKDS KRINIVPYTQ PNSLWRGPDE DDLDSNEKLD VHVVFNEGND KITVFFNGDY 180
  181 AVFLSVDNIE NENSLKSIIK VQDGFYQCFY EDGTVQTLNL GPLLQSKSSV NLLNYIMVIK 240
  241 ELIGYMLTHL EFINRELATP YLDFVKRLCD EAYGYGKLKS ELEALFLLGE ISCDLEDWLC 300
  301 NSVGEKNFKR WKYLGCEAYQ KTVQILTLIF VPACERIIIY VEKLRAILQA FSIQNKLSYT 360
  361 SDLTAVEVLL KSSQKLLTMT LNSIIGLGRD ETLFEKFFIW FNDRLHEALD EDYKLKFQFE 420
  421 DDLYFGYDLL SYFDRILSKK GTEPSSIIDV KLYRDLINSM SDMEKDIAQS NVNSHIQQHI 480
  481 LVDLKTDVFA QKYPSSQINL LDAIKLPKHN YIVYLIQVTK HNSAQEPFSE ENKKKLYIGT 540
  541 LKDENLGIIS KESSVKIPAL FKSYRLSSTR FVPNRVHSLL RDIGLSDSNY HSSHVTDYRG 600
  601 ENYENEEDDG TIAIPAYIRE NRENDDFIAC TAKVSVDGRS ASLVFPKEKQ NV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC27 DOC1
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
    View Details Gavin AC, et al. (2006) APC1 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC27
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] deduced N/A No confident structure predictions are available.
    2 View Details [156..395]
    [436..521]    		 ORFEUS 7.39 Hemolysin E (HlyE, ClyA, SheA)
    3 View Details [396..435] ORFEUS 7.39 Hemolysin E (HlyE, ClyA, SheA)
    4 View Details [522..652] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle