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View Structure Prediction Details

Protein: APC4
Organism: Saccharomyces cerevisiae
Length: 652 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APC4.

Description E-value Query
Range
Subject
Range
APC4_YEAST - Anaphase-promoting complex subunit 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APC...
APC4 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase req...
0.0 [1..652] [1..652]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPINDYFI DYNPLFPIFA TRIAKGLAIY RVSDHARLAV IPIRNINLVA NYDWDTTTGK  60
   61 FLSIFFKDGT IRIHDIFKDG RLVSFLRIPS TKISKGIWDR IPLRYEPNNR DFACNIIDDL 120
  121 PKLIRFVKDS KRINIVPYTQ PNSLWRGPDE DDLDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [156-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEKLDVHVVF NEGNDKITVF FNGDYAVFLS VDNIENENSL KSIIKVQDGF YQCFYEDGTV  60
   61 QTLNLGPLLQ SKSSVNLLNY IMVIKELIGY MLTHLEFINR ELATPYLDFV KRLCDEAYGY 120
  121 GKLKSELEAL FLLGEISCDL EDWLCNSVGE KNFKRWKYLG CEAYQKTVQI LTLIFVPACE 180
  181 RIIIYVEKLR AILQAFSIQN KLSYTSDLTA VEVLLKSSQK LLTMTLNSII GLGRDETLFE 240
  241 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [436-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILSKKGTEPS SIIDVKLYRD LINSMSDMEK DIAQSNVNSH IQQHILVDLK TDVFAQKYPS  60
   61 SQINLLDAIK LPKHNYIVYL IQVTKH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.39
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [396-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFFIWFNDRL HEALDEDYKL KFQFEDDLYF GYDLLSYFDR 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.39
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [522-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSAQEPFSEE NKKKLYIGTL KDENLGIISK ESSVKIPALF KSYRLSSTRF VPNRVHSLLR  60
   61 DIGLSDSNYH SSHVTDYRGE NYENEEDDGT IAIPAYIREN RENDDFIACT AKVSVDGRSA 120
  121 SLVFPKEKQN V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle