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The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex that regulates the mitotic metaphase/anaphase transition. Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
Acc: GO:0031145
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
Synonyms:
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation
  • APC-dependent proteasomal ubiquitin-dependent protein catabolism
  • APC-dependent proteasomal ubiquitin-dependent protein catabolic process
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism
Proteins in PDR annotated with:
   This term: 116 [Search]
   Term or descendants: 124 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle