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Protein Overview: CDC27

General Information:
Name(s) found: CDC27 / YBL084C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDALink to PubMed article][IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVNPELAPF TLSRGIPSFD DQALSTIIQL QDCIQQAIQQ LNYSTAEFLA ELLYAECSIL  60
   61 DKSSVYWSDA VYLYALSLFL NKSYHTAFQI SKEFKEYHLG IAYIFGRCAL QLSQGVNEAI 120
  121 LTLLSIINVF SSNSSNTRIN MVLNSNLVHI PDLATLNCLL GNLYMKLDHS KEGAFYHSEA 180
  181 LAINPYLWES YEAICKMRAT VDLKRVFFDI AGKKSNSHNN NAASSFPSTS LSHFEPRSQP 240
  241 SLYSKTNKNG NNNINNNVNT LFQSSNSPPS TSASSFSSIQ HFSRSQQQQA NTSIRTCQNK 300
  301 NTQTPKNPAI NSKTSSALPN NISMNLVSPS SKQPTISSLA KVYNRNKLLT TPPSKLLNND 360
  361 RNHQNNNNNN NNNNNNNNNN NNNNNNNNII NKTTFKTPRN LYSSTGRLTT SKKNPRSLII 420
  421 SNSILTSDYQ ITLPEIMYNF ALILRSSSQY NSFKAIRLFE SQIPSHIKDT MPWCLVQLGK 480
  481 LHFEIINYDM SLKYFNRLKD LQPARVKDME IFSTLLWHLH DKVKSSNLAN GLMDTMPNKP 540
  541 ETWCCIGNLL SLQKDHDAAI KAFEKATQLD PNFAYAYTLQ GHEHSSNDSS DSAKTCYRKA 600
  601 LACDPQHYNA YYGLGTSAMK LGQYEEALLY FEKARSINPV NVVLICCCGG SLEKLGYKEK 660
  661 ALQYYELACH LQPTSSLSKY KMGQLLYSMT RYNVALQTFE ELVKLVPDDA TAHYLLGQTY 720
  721 RIVGRKKDAI KELTVAMNLD PKGNQVIIDE LQKCHMQE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APC1 APC2 APC4 CDC16 CDC23 CDC27
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
    View Details Gavin AC, et al. (2006) APC1 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC27
    View Details Gavin AC, et al. (2002) ACT1 APC1 APC2 CDC16 CDC23 CDC27
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1 MND2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC27 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94]
    [205..212]    		 ORFEUS 8.93 Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
    2 View Details [95..154] ORFEUS 8.93 Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
    3 View Details [155..204] ORFEUS 8.93 Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
    4 View Details [213..428] ORFEUS 7.73 No description for 1ldvA was found.
    5 View Details [429..588] PSI-BLAST 122.9794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    6 View Details [589..656] PSI-BLAST 122.9794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    7 View Details [657..758] PSI-BLAST 122.9794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.66926716799278 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.842516597141339 bayes_pls_golite062009
  • catalytic activity
    		•  0.838457647933563 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  0.788209490718562 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  0.728844238348547 bayes_pls_golite062009
  • protein kinase activity
    		•  0.368415465331841 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.160297158628942 bayes_pls_golite062009
  • protein binding
    		•  0.0815963073690659 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0284131677759829 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  6.63746543212322 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.37753885031863 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.68162115570289 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.89523122092864 bayes_pls_golite062009
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • ligase activity
    		•  1.72049482453565 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • hydrolase activity
    		•  0.619711232527193 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.584434683111562 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.41706917101675 bayes_pls_golite062009
  • DNA binding
    		•  0.31557320489611 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle