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Protein Overview: APC5

General Information:
Name(s) found: APC5 / YOR249C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 685 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IPILink to PubMed article]
    chromatin assembly or disassembly [IMPLink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYGPLGIT NFITPYDLCI LILIHAHCSQ DNGISVPTAV FLRLISPTRP SLEWNPLLKD  60
   61 NSNLRSSSIV PPPVLPILDN IIRILLDDKD GNKIALTLMG YLEAINGLDS INRLMMDLEK 120
  121 NCLVNNYRSM KMRTTSTRRQ MTRASFLGTF LSTCIRKYQI GDFEMRETIW INLQNFKTVF 180
  181 KHTPLWLRFK DNVHIQKVKN CLLANDEISV EDQQMVEFFQ HFNNGNDADS KTMNEENYGT 240
  241 LISIQHLQSI VNRQIVNWLD NTEFNLMGQE ETSSTYEEQS GLVFDLLDTL SLNDATKFPL 300
  301 IFILKYLEAI KENSYQTALD SLHNYFDYKS TGNSQNYFHI SLLSLATFHS SFNECDAAIN 360
  361 SFEEATRIAR ENKDMETLNL IMIWIINFIE VHPEYANRFY ITVEQIIKYL KNSSDVEDAN 420
  421 IFSNAYKFET LLSMVKESKT AEVSSSLLKF MAITLQNVPS QNFDLFQSLV SYEVKFWKEL 480
  481 GYESISDVYE KFLSKTSSSS LRNYDSSIIN QDIKVAFKAL EEDDFLKVKQ YLLKSESLEL 540
  541 DYDQKINLKY LRVKYLVKIG DYDLSMRLIN QYVKECCEEV ADSNWRFKFE IESINVLLLS 600
  601 DVGIRSLPKI IKLIDEYKEI GNPLRCVILL LKLCEVLIQV GKSMEAECLI SCNLSTILEF 660
  661 PFVRKKTDEL LESLSVEEDR DVQMT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APC1 APC2 APC4 APC5 CDC23
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
    View Details Gavin AC, et al. (2006) APC1 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC27
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen APC5 YML131W 2 Unpublished Fields Lab Data
    View Screen APC5 NFI1 2 Unpublished Fields Lab Data
    View Screen APC5 YDR132C 2 Unpublished Fields Lab Data
    View Screen APC5 YDR026C 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data APC5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..223] MSA 1.00996 View MSA. No confident structure predictions are available.
    2 View Details [224..282] deduced N/A No confident structure predictions are available.
    3 View Details [283..385] ORFEUS 9.5 Transcription factor MalT domain III
    4 View Details [386..512] ORFEUS 9.5 Transcription factor MalT domain III
    5 View Details [513..685] ORFEUS 9.5 Transcription factor MalT domain III

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  6.60409233943418 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.34821407430872 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.66913998827366 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.89633630562107 bayes_pls_golite062009
  • binding
    		•  2.50062202757362 bayes_pls_golite062009
  • ligase activity
    		•  1.73009430374312 bayes_pls_golite062009
  • protein binding
    		•  1.72061787550863 bayes_pls_golite062009
  • hydrolase activity
    		•  0.63851966218836 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.437277381081288 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.198767743012145 bayes_pls_golite062009
  • DNA binding
    		•  0.186035324819401 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle