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View Structure Prediction Details

Protein: APC5
Organism: Saccharomyces cerevisiae
Length: 685 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APC5.

Description E-value Query
Range
Subject
Range
APC5 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase req...
APC5_YEAST - Anaphase-promoting complex subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APC...
0.0 [1..685] [1..685]
gi|16904253 - gi|16904253|gb|AAL30834.1|AF440398_2 anaphase-promoting complex protein [Mycosphaerella graminicola]
0.0 [12..400] [4..356]
gi|6692677, gi|2... - gi|6692677|gb|AAF24811.1|AC007592_4 F12K11.7 [Arabidopsis thaliana], pir||C86201 protein F12K11.7 [i...
2.0E-99 [13..388] [13..339]
gi|114647432, gi... - gi|114647434|ref|XP_001166188.1| PREDICTED: anaphase-promoting complex subunit 5 isoform 12 [Pan tro...
ANAPC5 - anaphase promoting complex subunit 5
gi|55726370 - gi|55726370|emb|CAH89955.1| hypothetical protein [Pongo abelii]
APC5_PONAB - Anaphase-promoting complex subunit 5 OS=Pongo abelii GN=ANAPC5 PE=2 SV=1
4.0E-97 [8..408] [25..366]
gi|18920374 - gi|18920374|gb|AAL82192.1|AF312026_1 IDA [Drosophila melanogaster]
5.0E-80 [14..393] [46..388]
gi|7670450, gi|1... - gi|7670450|dbj|BAA95076.1| unnamed protein product [Mus musculus], gi|10946920|ref|NP_067480.1| anap...
3.0E-73 [8..346] [13..293]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYGPLGIT NFITPYDLCI LILIHAHCSQ DNGISVPTAV FLRLISPTRP SLEWNPLLKD  60
   61 NSNLRSSSIV PPPVLPILDN IIRILLDDKD GNKIALTLMG YLEAINGLDS INRLMMDLEK 120
  121 NCLVNNYRSM KMRTTSTRRQ MTRASFLGTF LSTCIRKYQI GDFEMRETIW INLQNFKTVF 180
  181 KHTPLWLRFK DNVHIQKVKN CLLANDEISV EDQQMVEFFQ HFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [224-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGNDADSKTM NEENYGTLIS IQHLQSIVNR QIVNWLDNTE FNLMGQEETS STYEEQSGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 6.60409233943418 bayes_pls_golite062009
small conjugating protein ligase activity 6.34821407430872 bayes_pls_golite062009
acid-amino acid ligase activity 5.66913998827366 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.89633630562107 bayes_pls_golite062009
binding 2.50062202757362 bayes_pls_golite062009
ligase activity 1.73009430374312 bayes_pls_golite062009
protein binding 1.72061787550863 bayes_pls_golite062009
hydrolase activity 0.63851966218836 bayes_pls_golite062009
nucleic acid binding 0.437277381081288 bayes_pls_golite062009
transcription regulator activity 0.198767743012145 bayes_pls_golite062009
DNA binding 0.186035324819401 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [283-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFDLLDTLSL NDATKFPLIF ILKYLEAIKE NSYQTALDSL HNYFDYKSTG NSQNYFHISL  60
   61 LSLATFHSSF NECDAAINSF EEATRIAREN KDMETLNLIM IWI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [386-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INFIEVHPEY ANRFYITVEQ IIKYLKNSSD VEDANIFSNA YKFETLLSMV KESKTAEVSS  60
   61 SLLKFMAITL QNVPSQNFDL FQSLVSYEVK FWKELGYESI SDVYEKFLSK TSSSSLRNYD 120
  121 SSIINQD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [513-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKVAFKALEE DDFLKVKQYL LKSESLELDY DQKINLKYLR VKYLVKIGDY DLSMRLINQY  60
   61 VKECCEEVAD SNWRFKFEIE SINVLLLSDV GIRSLPKIIK LIDEYKEIGN PLRCVILLLK 120
  121 LCEVLIQVGK SMEAECLISC NLSTILEFPF VRKKTDELLE SLSVEEDRDV QMT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle