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View Structure Prediction Details

Protein: APC5
Organism: Saccharomyces cerevisiae
Length: 685 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APC5.

Description E-value Query
Range
Subject
Range
APC5 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase req...
APC5_YEAST - Anaphase-promoting complex subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APC...
0.0 [1..685] [1..685]
gi|16904253 - gi|16904253|gb|AAL30834.1|AF440398_2 anaphase-promoting complex protein [Mycosphaerella graminicola]
0.0 [12..400] [4..356]
gi|6692677, gi|2... - gi|6692677|gb|AAF24811.1|AC007592_4 F12K11.7 [Arabidopsis thaliana], pir||C86201 protein F12K11.7 [i...
2.0E-99 [13..388] [13..339]
gi|114647432, gi... - gi|114647434|ref|XP_001166188.1| PREDICTED: anaphase-promoting complex subunit 5 isoform 12 [Pan tro...
ANAPC5 - anaphase promoting complex subunit 5
gi|55726370 - gi|55726370|emb|CAH89955.1| hypothetical protein [Pongo abelii]
APC5_PONAB - Anaphase-promoting complex subunit 5 OS=Pongo abelii GN=ANAPC5 PE=2 SV=1
4.0E-97 [8..408] [25..366]
gi|18920374 - gi|18920374|gb|AAL82192.1|AF312026_1 IDA [Drosophila melanogaster]
5.0E-80 [14..393] [46..388]
gi|7670450, gi|1... - gi|7670450|dbj|BAA95076.1| unnamed protein product [Mus musculus], gi|10946920|ref|NP_067480.1| anap...
3.0E-73 [8..346] [13..293]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYGPLGIT NFITPYDLCI LILIHAHCSQ DNGISVPTAV FLRLISPTRP SLEWNPLLKD  60
   61 NSNLRSSSIV PPPVLPILDN IIRILLDDKD GNKIALTLMG YLEAINGLDS INRLMMDLEK 120
  121 NCLVNNYRSM KMRTTSTRRQ MTRASFLGTF LSTCIRKYQI GDFEMRETIW INLQNFKTVF 180
  181 KHTPLWLRFK DNVHIQKVKN CLLANDEISV EDQQMVEFFQ HFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [224-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGNDADSKTM NEENYGTLIS IQHLQSIVNR QIVNWLDNTE FNLMGQEETS STYEEQSGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.222 a.4.1 Homeodomain-like
View Download 0.425 g.41.3 Zinc beta-ribbon
View Download 0.284 a.64.1 Saposin
View Download 0.300 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 6.60409233943418 bayes_pls_golite062009
small conjugating protein ligase activity 6.34821407430872 bayes_pls_golite062009
acid-amino acid ligase activity 5.66913998827366 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.89633630562107 bayes_pls_golite062009
binding 2.50062202757362 bayes_pls_golite062009
ligase activity 1.73009430374312 bayes_pls_golite062009
protein binding 1.72061787550863 bayes_pls_golite062009
hydrolase activity 0.63851966218836 bayes_pls_golite062009
nucleic acid binding 0.437277381081288 bayes_pls_golite062009
transcription regulator activity 0.198767743012145 bayes_pls_golite062009
DNA binding 0.186035324819401 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [283-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFDLLDTLSL NDATKFPLIF ILKYLEAIKE NSYQTALDSL HNYFDYKSTG NSQNYFHISL  60
   61 LSLATFHSSF NECDAAINSF EEATRIAREN KDMETLNLIM IWI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [386-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INFIEVHPEY ANRFYITVEQ IIKYLKNSSD VEDANIFSNA YKFETLLSMV KESKTAEVSS  60
   61 SLLKFMAITL QNVPSQNFDL FQSLVSYEVK FWKELGYESI SDVYEKFLSK TSSSSLRNYD 120
  121 SSIINQD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [513-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKVAFKALEE DDFLKVKQYL LKSESLELDY DQKINLKYLR VKYLVKIGDY DLSMRLINQY  60
   61 VKECCEEVAD SNWRFKFEIE SINVLLLSDV GIRSLPKIIK LIDEYKEIGN PLRCVILLLK 120
  121 LCEVLIQVGK SMEAECLISC NLSTILEFPF VRKKTDELLE SLSVEEDRDV QMT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.5
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle