YRC Public Data Repository - Protein Structure Prediction

Protein:	CDC27
Organism:	Saccharomyces cerevisiae
Length:	758 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC27.

Description	E-value	Query Range	Subject Range
CDC27 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase req...	0.0	[1..758]	[1..758]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[28..745]	[6..771]
gi\|168275840 - gi\|168275840\|dbj\|BAG10640.1\| cell division cycle protein 27 homolog [synthetic construct] CDC27 - cell division cycle 27 homolog (S. cerevisiae)	0.0	[28..745]	[6..772]
BIMA_EMENI - Protein bimA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=... BIMA_EMENI - Protein bimA OS=Emericella nidulans GN=bimA PE=2 SV=1	2.0E-94	[29..754]	[11..795]
gi\|13775066 - gi\|13775066\|gb\|AAK39123.1\|AF363030_1 UDP-N-acetylglucosaminyltransferase [Mus musculus]	2.0E-91	[297..755]	[19..474]
OGT1_RAT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicu...	5.0E-91	[290..755]	[2..464]
gi\|5052534 - gi\|5052534\|gb\|AAD38597.1\|AF145622_1 BcDNA.GH04245 [Drosophila melanogaster]	4.0E-90	[268..755]	[19..503]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVNPELAPF TLSRGIPSFD DQALSTIIQL QDCIQQAIQQ LNYSTAEFLA ELLYAECSIL  60
   61 DKSSVYWSDA VYLYALSLFL NKSYHTAFQI SKEF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [205-212]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVFFDIAG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.93
Match:	1hh8A
Description:	Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.66926716799278	bayes_pls_golite062009
transcription regulator activity	0.842516597141339	bayes_pls_golite062009
catalytic activity	0.838457647933563	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	0.788209490718562	bayes_pls_golite062009
cis-trans isomerase activity	0.728844238348547	bayes_pls_golite062009
protein kinase activity	0.368415465331841	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.160297158628942	bayes_pls_golite062009
protein binding	0.0815963073690659	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0284131677759829	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [95-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEYHLGIAYI FGRCALQLSQ GVNEAILTLL SIINVFSSNS SNTRINMVLN SNLVHIPDLA  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.93
Match:	1hh8A
Description:	Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [155-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLNCLLGNLY MKLDHSKEGA FYHSEALAIN PYLWESYEAI CKMRATVDLK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.93
Match:	1hh8A
Description:	Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	6.63746543212322	bayes_pls_golite062009
small conjugating protein ligase activity	6.37753885031863	bayes_pls_golite062009
acid-amino acid ligase activity	5.68162115570289	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	4.89523122092864	bayes_pls_golite062009
binding	2.71974493738804	bayes_pls_golite062009
ligase activity	1.72049482453565	bayes_pls_golite062009
protein binding	1.6279032205159	bayes_pls_golite062009
hydrolase activity	0.619711232527193	bayes_pls_golite062009
transcription regulator activity	0.584434683111562	bayes_pls_golite062009
nucleic acid binding	0.41706917101675	bayes_pls_golite062009
DNA binding	0.31557320489611	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [213-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKSNSHNNNA ASSFPSTSLS HFEPRSQPSL YSKTNKNGNN NINNNVNTLF QSSNSPPSTS  60
   61 ASSFSSIQHF SRSQQQQANT SIRTCQNKNT QTPKNPAINS KTSSALPNNI SMNLVSPSSK 120
  121 QPTISSLAKV YNRNKLLTTP PSKLLNNDRN HQNNNNNNNN NNNNNNNNNN NNNNNNIINK 180
  181 TTFKTPRNLY SSTGRLTTSK KNPRSLIISN SILTSD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.73
Match:	1ldvA
Description:	No description for 1ldvA was found.

Predicted Domain #5

Region A:
Residues: [429-588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQITLPEIMY NFALILRSSS QYNSFKAIRL FESQIPSHIK DTMPWCLVQL GKLHFEIINY  60
   61 DMSLKYFNRL KDLQPARVKD MEIFSTLLWH LHDKVKSSNL ANGLMDTMPN KPETWCCIGN 120
  121 LLSLQKDHDA AIKAFEKATQ LDPNFAYAYT LQGHEHSSND

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	122.9794
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [589-656]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSDSAKTCYR KALACDPQHY NAYYGLGTSA MKLGQYEEAL LYFEKARSIN PVNVVLICCC  60
   61 GGSLEKLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	122.9794
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [657-758]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKEKALQYYE LACHLQPTSS LSKYKMGQLL YSMTRYNVAL QTFEELVKLV PDDATAHYLL  60
   61 GQTYRIVGRK KDAIKELTVA MNLDPKGNQV IIDELQKCHM QE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	122.9794
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: