YRC Public Data Repository - Protein Structure Prediction

Protein:	DOC1
Organism:	Saccharomyces cerevisiae
Length:	250 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOC1.

Description	E-value	Query Range	Subject Range
DOC1 - Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC)... gi\|190407173 - gi\|190407173\|gb\|EDV10440.1\| anaphase promoting complex subunit 10 [Saccharomyces cerevisiae RM11-1a] APC10_YEAST - Anaphase-promoting complex subunit DOC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... gi\|151943579 - gi\|151943579\|gb\|EDN61889.1\| conserved protein [Saccharomyces cerevisiae YJM789]	1.0E-88	[1..250]	[1..250]
gi\|45198790, gi\|... - gi\|45198790\|ref\|NP_985819.1\| AFR272Wp [Ashbya gossypii ATCC 10895], gi\|44984819\|gb\|AAS53643.1\| AFR27... gi\|44984819 - gi\|44984819\|gb\|AAS53643.1\| AFR272Wp [Ashbya gossypii ATCC 10895]	5.0E-58	[32..222]	[31..221]
APC10_ARATH - Anaphase-promoting complex subunit 10 OS=Arabidopsis thaliana GN=APC10 PE=1 SV=2	1.0E-57	[72..230]	[18..178]
gi\|85110707 - gi\|85110707\|ref\|XP_963592.1\| hypothetical protein ( (AL513409) related to anaphase promoting complex... gi\|12718366, gi\|... - gi\|32420809\|ref\|XP_330848.1\| hypothetical protein ( (AL513409) related to anaphase promoting complex...	3.0E-55	[34..225]	[133..330]
gi\|5091606 - gi\|5091606\|gb\|AAD39595.1\|AC007858_9 10A19I.10 [Oryza sativa (japonica cultivar-group)]	1.0E-52	[73..231]	[28..188]
gi\|4836700 - gi\|4836700\|gb\|AAD30527.1\| anaphase promoting complex subunit 10 [Homo sapiens]	2.0E-50	[72..227]	[12..166]
gi\|195335261, gi... - gi\|195335261\|ref\|XP_002034293.1\| GM19974 [Drosophila sechellia], gi\|194126263\|gb\|EDW48306.1\| GM19974... CG11419-PA - This gene is referred to in FlyBase by the symbol Dmel\CG11419 (CG11419, FBgn0034231). It is a prote... gi\|195584242, gi... - gi\|195584242\|ref\|XP_002081923.1\| GD25470 [Drosophila simulans], gi\|194193932\|gb\|EDX07508.1\| GD25470 ... gi\|220957430, gi... - gi\|220957430\|gb\|ACL91258.1\| CG11419-PA [synthetic construct], gi\|220948260\|gb\|ACL86673.1\| CG11419-PA...	2.0E-50	[82..229]	[31..176]

Back

Predicted Domain #1

Region A:
Residues: [1-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPIGINKVL DHLAPSELIK PVKSCHNKPS VLVLDDRIVD AATKDLYVNG FQEEIQYQNP  60
   61 TPENLQHMFH QGIEILDSAR MINVTHLALW KPSSFKLGNP VDFALDDNYD TFWQSDGGQP 120
  121 HQLDIMFSKR MDICVMAIFF SMIADESYAP SLVKVYAGHS PSDARFYKML EVRNVNGWVA 180
  181 LRFLDNREDD QLLKCQFIRL LFPVNHENGK DTHLRGIRLY VPSNEPHQDT HEWAQTLPET 240
  241 NNVFQDAILR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.69897
Match:	1gqpA_
Description:	APC10/DOC1 subunit of the anaphase-promoting complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	8.2536490347155	bayes_pls_golite062009
small conjugating protein ligase activity	7.94028983948676	bayes_pls_golite062009
acid-amino acid ligase activity	6.95223443027718	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	5.78575924847122	bayes_pls_golite062009
ligase activity	2.23368019733876	bayes_pls_golite062009
binding	2.16986209889839	bayes_pls_golite062009
protein binding	1.06560945718583	bayes_pls_golite062009
hydrolase activity	0.690426836233441	bayes_pls_golite062009
protein kinase activity	0.615340190084121	bayes_pls_golite062009
nucleic acid binding	0.533285414042183	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.289551445698612	bayes_pls_golite062009
kinase activity	0.197678597934074	bayes_pls_golite062009
DNA binding	0.186569142108209	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.185939854910418	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: