Protein Overview: DOC1

General Information:
Name(s) found:	DOC1 / YGL240W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|55584167\|sp\|P53068.2\|APC10_YEAST RecName: Full=Anaphase-promoting complex subunit DOC1; AltName: Full=Destruction of cyclin B protein 1 [NCBI NR] gi\|37362650\|ref\|NP_011274.2\| Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; Doc1p [Saccharomy [NCBI NR] Anaphase-promoting complex subunit DOC1 OS=Saccharomyces cerevisiae GN=DOC1 PE=1 SV=2 [Swiss-Prot] DOC1 Component of the anaphase promoting complex [mips] Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis [SGD] Chr VII from 48613-49365 [yeastorf5.fasta] DOC1 SGDID:S0003209, Chr VII from 48613-49365, Verified ORF [yeastflysequest.fasta] Doc1p [Saccharomyces cerevisiae]gi\|55584167\|sp\|P53068\|AP10_YEAST Anaphase promoting complex subunit DOC1 (Destruction of cyclin B protein 1) [nrdb_11152004_Chlamydomonas] DOC1 SGDID:S000003209, Chr VII from 48613-49365, Verified ORF, "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cy [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Anaphase-promoting complex subunit DOC1 (Destruction of cyclin B protein 1) [nr-271106-contam.fasta] Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; Doc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DOC1 SGDID:S000003209, Chr VII from 48613-49365, Verified ORF, "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Anaphase-promoting complex subunit DOC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DOC1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] DOC1 SGDID:S000003209, Chr VII from 48613-49365, Genome Release 64-1-1, Verified ORF, "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain" [yeast-030211-contam.fasta] DOC1 SGDID:S000003209, Chr VII from 48613-49365, Genome Release 64-2-1, Verified ORF, "Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain" [20141208_orf_trans.fasta] YGL240W SGDID:S000003209, Chr VII from 48613-49365, Genome Release 64-1-1, Verified ORF, "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	250 amino acids
Gene Ontology:
Cellular Component:	anaphase-promoting complex [TAS] mitochondrion [IDA ]
Biological Process:	mitotic spindle elongation [TAS] cyclin catabolic process [TAS] mitotic sister chromatid segregation [TAS] anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA][IMP][IPI] mitotic metaphase/anaphase transition [TAS]
Molecular Function:	enzyme regulator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPIGINKVL DHLAPSELIK PVKSCHNKPS VLVLDDRIVD AATKDLYVNG FQEEIQYQNP  60
   61 TPENLQHMFH QGIEILDSAR MINVTHLALW KPSSFKLGNP VDFALDDNYD TFWQSDGGQP 120
  121 HQLDIMFSKR MDICVMAIFF SMIADESYAP SLVKVYAGHS PSDARFYKML EVRNVNGWVA 180
  181 LRFLDNREDD QLLKCQFIRL LFPVNHENGK DTHLRGIRLY VPSNEPHQDT HEWAQTLPET 240
  241 NNVFQDAILR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		APC2 APC4 DOC1
View Details	(MIPS) Mewes HW, et al. (2004)		APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
View Details	Krogan NJ, et al. (2006)		APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
View Details	Qiu et al. (2008)		APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1 SWM1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	DOC1	SNA4	2	Unpublished Fields Lab Data
View Screen	DOC1	ATG7	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DOC1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..250]	PSI-BLAST	72.69897	APC10/DOC1 subunit of the anaphase-promoting complex

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ubiquitin-protein ligase activity	8.2536490347155	bayes_pls_golite062009
small conjugating protein ligase activity	7.94028983948676	bayes_pls_golite062009
acid-amino acid ligase activity	6.95223443027718	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	5.78575924847122	bayes_pls_golite062009
ligase activity	2.23368019733876	bayes_pls_golite062009
binding	2.16986209889839	bayes_pls_golite062009
protein binding	1.06560945718583	bayes_pls_golite062009
hydrolase activity	0.690426836233441	bayes_pls_golite062009
protein kinase activity	0.615340190084121	bayes_pls_golite062009
nucleic acid binding	0.533285414042183	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.289551445698612	bayes_pls_golite062009
kinase activity	0.197678597934074	bayes_pls_golite062009
DNA binding	0.186569142108209	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.185939854910418	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2