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Protein Overview: PGM1

General Information:
Name(s) found: PGM1 / YKL127W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 570 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: carbohydrate metabolic process [IEA]
    glycogen biosynthetic process [IGI]
    glucose 6-phosphate metabolic process [ISS]
    galactose catabolic process [IGI]
    glucose 1-phosphate metabolic process [IGI][ISS]
    trehalose biosynthetic process [IGI]
    UDP-glucose metabolic process [IGI]
    glucose metabolic process [IEA]
    Molecular Function: phosphoglucomutase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLIDSVPT VAYKDQKPGT SGLRKKTKVF MDEPHYTENF IQATMQSIPN GSEGTTLVVG  60
   61 GDGRFYNDVI MNKIAAVGAA NGVRKLVIGQ GGLLSTPAAS HIIRTYEEKC TGGGIILTAS 120
  121 HNPGGPENDL GIKYNLPNGG PAPESVTNAI WEASKKLTHY KIIKNFPKLN LNKLGKNQKY 180
  181 GPLLVDIIDP AKAYVQFLKE IFDFDLIKSF LAKQRKDKGW KLLFDSLNGI TGPYGKAIFV 240
  241 DEFGLPAEEV LQNWHPLPDF GGLHPDPNLT YARTLVDRVD REKIAFGAAS DGDGDRNMIY 300
  301 GYGPAFVSPG DSVAIIAEYA PEIPYFAKQG IYGLARSFPT SSAIDRVAAK KGLRCYEVPT 360
  361 GWKFFCALFD AKKLSICGEE SFGTGSNHIR EKDGLWAIIA WLNILAIYHR RNPEKEASIK 420
  421 TIQDEFWNEY GRTFFTRYDY EHIECEQAEK VVALLSEFVS RPNVCGSHFP ADESLTVIDC 480
  481 GDFSYRDLDG SISENQGLFV KFSNGTKFVL RLSGTGSSGA TIRLYVEKYT DKKENYGQTA 540
  541 DVFLKPVINS IVKFLRFKEI LGTDEPTVRT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHA1 HOM3 NTG1 OPY1 PGM1 PGM2 PRB1 RAD59 RPB3 RPT3 SEC27
    View Details Qiu et al. (2008) PGM1 PGM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PGM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] PSI-BLAST 1672.0 Phosphoglucomutase
    2 View Details [193..306]
    [387..421]    		 PSI-BLAST 1672.0 Phosphoglucomutase
    3 View Details [307..386]
    [422..432]
    [484..494]    		 PSI-BLAST 1672.0 Phosphoglucomutase
    4 View Details [433..483]
    [495..570]    		 PSI-BLAST 1672.0 Phosphoglucomutase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoglucomutase activity
    		•  3.58264389178108 bayes_pls_golite062009
  • binding
    		•  1.81828980398861 bayes_pls_golite062009
  • structural molecule activity
    		•  1.71130645303643 bayes_pls_golite062009
  • intramolecular transferase activity, phosphotransferases
    		•  0.9938893438261 bayes_pls_golite062009
  • phosphomannomutase activity
    		•  0.96914970670646 bayes_pls_golite062009
  • catalytic activity
    		•  0.792640318995558 bayes_pls_golite062009
  • protein binding
    		•  0.359358565373414 bayes_pls_golite062009
  • isomerase activity
    		•  0.340395019264179 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle