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View Structure Prediction Details

Protein: CDC25
Organism: Saccharomyces cerevisiae
Length: 1589 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC25.

Description E-value Query
Range		 Subject
Range
CDC25_LACKL - Cell division control protein 25 (Fragment) OS=Lachancea kluyveri GN=CDC25 PE=3 SV=1
 0.0 [460..1585] [2..1089]
gi|3484 - gi|3484|emb|CAA27259.1| unnamed protein product [Saccharomyces cerevisiae]
 0.0 [1..1589] [1..1588]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [651..1555] [109..1010]
CDC25_CANAL, CC2... - Cell division control protein 25 OS=Candida albicans GN=CDC25 PE=4 SV=1, (P43069) Cell division cont...
CDC25_CANAL - Cell division control protein 25 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC25 PE=3 S...
 0.0 [851..1568] [658..1331]
SOS2 - son of sevenless homolog 2 (Drosophila)
 0.0 [1028..1570] [513..1044]

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Predicted Domain #1
Region A:
Residues: [1-129] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTNTSIPN TSSAREAGNA SQTPSISSSS NTSTTTNTES SSASLSSSPS TSELTSIRPI  60
   61 GIVVAAYDFN YPIKKDSSSQ LLSVQQGETI YILNKNSSGW WDGLVIDDSN GKVNRGWFPQ 120
  121 NFGRPLRDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.69897
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 3.13508395312263 bayes_pls_golite062009
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
binding 3.12724619324809 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.02111138016453 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
kinase regulator activity 0.69502098407037 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
enzyme regulator activity 0.456661966897198 bayes_pls_golite062009
nucleic acid binding 0.352421112301971 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
cytoskeletal protein binding 0.0898978787421796 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [130-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLRKHSHPMK KYSSSKSSRR SSLNSLGNSA YLHVPRNPSK SRRGSSTLSA SLSNAHNAET  60
   61 SSGHNNTVSM NNSPFSAPND ASHITPQSSN FNSNASLSQD MTKSADGSSE MNTNAIMNNN 120
  121 ETNLQTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.69897
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [257-975] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEKAGPPLVA EETIKILPLE EIEMIINGIR SNIASTWSPI PLITKTSDYK LVYYNKDLDI  60
   61 YCSELPLISN SIMESDDICD SEPKFPPNDH LVNLYTRDLR KNANIEDSST RSKQSESEQN 120
  121 RSSLLMEKQD SKETDGNNNS INDDDNNNEN NKNEFNEAGP SSLNSLSAPD LTQNIQSRVV 180
  181 APSRSSILAK SDIFYHYSRD IKLWTELQDL TVYYTKTAHK MFLKENRLNF TKYFDLISDS 240
  241 IVFTQLGCRL MQHEIKAKSC SKEIKKIFKG LISSLSRISI NSHLYFDSAF HRKKMDTMND 300
  301 KDNDNQENNC SRTEGDDGKI EVDSVHDLVS VPLSGKRNVS TSTTDTLTPM RSSFSTVNEN 360
  361 DMENFSVLGP RNSVNSVVTP RTSIQNSTLE DFSPSNKNFK SAKSIYEMVD VEFSKFLRHV 420
  421 QLLYFVLQSS VFSDDNTLPQ LLPRFFKGSF SGGSWTNPFS TFITDEFGNA TKNKAVTSNE 480
  481 VTASSSKNSS ISRIPPKMAD AIASASGYSA NSETNSQIDL KASSAASGSV FTPFNRPSHN 540
  541 RTFSRARVSK RKKKYPLTVD TLNTMKKKSS QIFEKLNNAT GEHLKIISKP KSRIRNLEIN 600
  601 SSTYEQINQN VLLLEILENL DLSIFINLKN LIKTPSILLD LESEEFLVHA MSSVSSVLTE 660
  661 FFDIKQAFHD IVIRLIMTTQ QTTLDDPYLF SSMRSNFPVG HHEPFKNISN TPLVKGPFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [976-1079] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKNEQLALSL FHVLVSQDVE FNNLEFLNNS DDFKDACEKY VEISNLACII VDQLIEEREN  60
   61 LLNYAARMMK NNLTAELLKG EQEKWFDIYS EDYSDDDSEN DEAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1awe__
Description: Son of sevenless-1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1080-1263] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDDELGSEDY IERKAANIEK NLPWFLTSDY ETSLVYDSRG KIRGGTKEAL IEHLTSHELV  60
   61 DAAFNVTMLI TFRSILTTRE FFYALIYRYN LYPPEGLSYD DYNIWIEKKS NPIKCRVVNI 120
  121 MRTFLTQYWT RNYYEPGIPL ILNFAKMVVS EKIPGAEDLL QKINEKLINE NEKEPVDPKQ 180
  181 QDSV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1467-1494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFTFVGNPDF LHNSTNIINF SKRTKIAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 488.0
Match: 1bkdS_
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1264-1466] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVVQTTKRD NKSPIHMSSS SLPSSASSAF FRLKKLKLLD IDPYTYATQL TVLEHDLYLR  60
   61 ITMFECLDRA WGTKYCNMGG SPNITKFIAN ANTLTNFVSH TIVKQADVKT RSKLTQYFVT 120
  121 VAQHCKELNN FSSMTAIVSA LYSSPIYRLK KTWDLVSTES KDLLKNLNNL MDSKRNFVKY 180
  181 RELLRSVTDV ACVPFFGVYL SDL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1495-1589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVEEIISFKR FHYKLKRLDD IQTVIEASLE NVPHIEKQYQ LSLQVEPRSG NTKGSTHASS  60
   61 ASGTKTAKFL SEFTDDKNGN FLKLGKKKPP SRLFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 488.0
Match: 1bkdS_
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.29080729281876 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
small GTPase binding 0.8507658747425 bayes_pls_golite062009
GTPase binding 0.82889812790119 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
receptor binding 0.50127063593663 bayes_pls_golite062009
receptor activity 0.353510125274044 bayes_pls_golite062009
transcription regulator activity 0.324566338715835 bayes_pls_golite062009
transmembrane receptor activity 0.207829786337892 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.13700176999256 bayes_pls_golite062009
DNA binding 0.136435190086451 bayes_pls_golite062009
nucleic acid binding 0.118897432176337 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle