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Protein Overview: SRP21

General Information:
Name(s) found: SRP21 / YKL122C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 167 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    signal recognition particle, endoplasmic reticulum targeting [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [ICLink to PubMed article]
    protein targeting to ER [IPILink to PubMed article]
    Molecular Function: signal sequence binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVKPIDNYI TNSVRLFEVN PSQTLFSISY KPPTQKTDTK VSFRTHNSHL SLNYKFTTNK  60
   61 SKDVSRLLSA LGPRGVSITP GKIEKIAQSK KKNNKIKESS KKIKGKSIQD IVGLATLIVN 120
  121 TDVEKSDPAA KKTATEPKQK ANAVQNNNGN SAASKKKKNK NKGKKKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details (MIPS) Mewes HW, et al. (2004) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Krogan NJ, et al. (2006) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
    View Details Gavin AC, et al. (2002) BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Qiu et al. (2008) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SRP21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle