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Protein Overview: SWI1

General Information:
Name(s) found: SWI1 / YPL016W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+] [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1314 amino acids

    Gene Ontology:
    Cellular Component: SWI/SNF complex [TASLink to PubMed article]
    chromatin remodeling complex [TASLink to PubMed article]
    Biological Process: chromatin remodeling [TASLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFFNLNNNN NNNNTTTTTT TTNNNNTNNN NTNNNNNPAN NTNNNNSTGH SSNTNNNTNN  60
   61 NNTNTGASGV DDFQNFFDPK PFDQNLDSNN NNSNSNNNDN NNSNTVASST NFTSPTAVVN 120
  121 NAAPANVTGG KAANFIQNQS PQFNSPYDSN NSNTNLNSLS PQAILAKNSI IDSSNLPLQA 180
  181 QQQLYGGNNN NNSTGIANDN VITPHFITNV QSISQNSSSS TPNTNSNSTP NANQQFLPFN 240
  241 NSASNNGNLT SNQLISNYAA SNSMDRSSSA SNEFVPNTSD NNNNSNNHNM RNNSNNKTSN 300
  301 NNNVTAVPAA TPANTNNSTS NANTVFSERA AMFAALQQKQ QQRFQALQQQ QQQQQNQQQQ 360
  361 NQQPQQQQQQ QQNPKFLQSQ RQQQQRSILQ SLNPALQEKI STELNNKQYE LFMKSLIENC 420
  421 KKRNMPLQSI PEIGNRKINL FYLYMLVQKF GGADQVTRTQ QWSMVAQRLQ ISDYQQLESI 480
  481 YFRILLPYER HMISQEGIKE TQAKRIFLQQ FLQELLKKVQ QQQQAAALAN ANNNINSASS 540
  541 APTPAAPGAS VPATAAPGTE AGIVPVSANT PKSLNSNINI NVNNNNIGQQ QVKKPRKQRV 600
  601 KKKTKKELEL ERKEREDFQK RQQKLLEDQQ RQQKLLLETK LRQQYEIELK KLPKVYKRSI 660
  661 VRNYKPLINR LKHYNGYDIN YISKIGEKID SNKPIFLFAP ELGAINLHAL SMSLQSKNLG 720
  721 EINTALNTLL VTSADSNLKI SLVKYPELLD SLAILGMNLL SNLSQNVVPY HRNTSDYYYE 780
  781 DAGSNQYYVT QHDKMVDKIF EKVNNNATLT PNDSNDEKVT ILVDSLTGNQ LPTPTPTEME 840
  841 PDLDTECFIS MQSTSPAVKQ WDLLPEPIRF LPNQFPLKIH RTPYLTSLKK IKDEIDDPFT 900
  901 KINTRGAEDP KVLINDQLST ISMILRNISF SDNNSRIMSR NFYLKRFISD LLWLVLIHPE 960
  961 NFTCNRKILN FKKDLVIVLS NISHLLEIAS SIDCLLILIL VISFGQPKLN PMASSSSFGS1020
 1021 ESLTFNEFQL QWGKYQTFGV DILAKLFSLE KPNLNYFKSI LLNKNTGNNL YDRNSNNNHK1080
 1081 DKKLLRRLLN LYNDNNKNNN NRHNLLNDVV SFLFSAIPLQ QVLSQSADPS LLIDQFSPVI1140
 1141 SQSLTSILVI VQKILPLSNE VFEISENNSD SNSNNNGNKD SSFNFNKNLP FVWLSSEENI1200
 1201 GSGLLKLSEI ILNINNSTSK NTLLQQQNYS KVLLPSINIS CVQLIKCLVE KSICFENCLN1260
 1261 NDPEILKKIA SIPNLFPTDL EIFQLFTNPS VDIQIINQYQ LLYNLKNDIL TNLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP7 ARP9 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 SWP82
    View Details (MIPS) Mewes HW, et al. (2004) ARP7 ARP9 SNF11 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 TAF14
    View Details Krogan NJ, et al. (2006) SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 SWP82
    View Details Gavin AC, et al. (2006) ARP9 SNF11 SNF12 SNF5 SNF6 SWI1 SWI3
    View Details Gavin AC, et al. (2002) ARP9 BEM2 DIM1 ENP1 HCA4 HRR25 IML1 LHP1 LTV1 NAB3 NAB6 NAM7 NOB1 NPL3 NRD1 NRP1 PNO1 POL2 PUB1 RIO2 RRP12 SGN1 SMD3 SNF12 SNF2 SNF5 SNF6 STO1 SWI1 SWI3 SWP82 TIF4631 TIF4632 TSR1 VPS1 YGR054W
    View Details Ho Y, et al. (2002) APL5 APM3 SWI1
    View Details Qiu et al. (2008) ARP7 ARP9 GAL11 SNF11 SNF12 SNF2 SNF5 SNF6 SWI1 SWI3 TAF14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SWI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..405] PSI-BLAST 8.154902 Botulinum neurotoxin
    2 View Details [406..548] PSI-BLAST 547.69897 Transcription regulator Adr6 (Swi1)
    3 View Details [549..908] deduced N/A No confident structure predictions are available.
    4 View Details [909..1066] MSA 1.002994 View MSA. No confident structure predictions are available.
    5 View Details [1067..1314] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.278956919805523 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle