| Protein: | BEM2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 2167 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BEM2.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..2167] | [1..2167] |
|
|
0.0 | [86..2165] | [12..2070] |
|
|
1.0E-90 | [1651..2167] | [1..541] |
|
|
6.0E-85 | [1651..2167] | [1..542] |
|
Region A: Residues: [1-575] |
1 11 21 31 41 51
| | | | | |
1 MKGLLWSKNR KSSTASASSS STSTSHKTTT ASTASSSSPS SSSQTIRNST SGASPYMHSH 60
61 HHHGQGHSHH RGEDNNRDKR KSSVFPPSKQ YTSTSSSQVN LGMYHSDTNT RSSRSIASTL 120
121 KDDSPSVCSE DEISNSSSQK SNAQDETPIA YKKSAHSKDS LLPSRSSSLS PPQSRCSTGT 180
181 TLEKSLNTSG ISNSSGTNNN NSNNNNDNEQ KQRNVIHLNS ENYDTTVFKT GWVNKSHGQT 240
241 VATNYNSSMT APSSSSSSSS QNLRNDAYSR NRESRFYGND GSSLKNDDSS STTATNSGND 300
301 VASARSSMAI DPQMLVPDYR LYRAQLKGCV LNLYKSGLNS NIKFFDPTLP ASNSSIANEN 360
361 HQQKKQQTNN QAQAEALHQK QSFGQMGEPI TLDLKYLSEV YPHPDLRQDS DGKIISGTIE 420
421 SLCHTVLFYP GPKQSDVPNE KSLSKTHRAV INLLLMFPLL DHFIKFLKVF NQFGLSFTKN 480
481 KSRLTNNSTQ FYNISPAVDD SMTQRLALTA KTILDVFPGF LLDEPMLKTI ISLLDTISLH 540
541 NDEISNNLKI KIANKHNELM KLTAFTRSLP MATSS
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [576-810] |
1 11 21 31 41 51
| | | | | |
1 THELEIILDP SHFLSLDITT LADEVHHINL KFDKVWAPKF DYSLLYDSKF INRRIVSLNP 60
61 LVFNNDQNIH FLGRLLISHL FPTNPEFSKK VTPKVRAELL DKWVQIGCRF EHLGDMVSWL 120
121 AVATIICSIP VLRSSSWKYV PDQSLKTIFK DWVPTIIQLE RRQRTSKSTS SVFILAPPNL 180
181 DDDFTRANVI SYFGDLLIHA DDLPSDTKFK YLEKKINRTK NAFHKWQQRL QAIDS
|
| Detection Method: | |
| Confidence: | 95.744727 |
| Match: | PF00617 |
| Description: | RasGEF domain |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [811-1104] |
1 11 21 31 41 51
| | | | | |
1 TRHKTNSTEN VRDNDSPNNV VYQLWKFHLS QPPLNIEGIM KLSVQHEPPI IDQKAYSTIG 60
61 SQRSALVTGS YLPILFNELF PNYSLFPKNT LVGAASDAKL PPPRSSARLS KSLSISEPIP 120
121 IASNSHTMGS LTDDAMSSKN DNNKVTGVGK IDGPVIKEMS SKQSNKQRLL KSVRDVFNID 180
181 MDVFHISDEL VFKSVYDNDG KSRPASMVIE TPKRFSQHSS MLINNPATPN QKMRDSLDTT 240
241 GRLSKTLENM DFFNNIGQVS DSLKESIIRV VLKSSSLEKI FDLLVLTSNI FSKL
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1105-1188] |
1 11 21 31 41 51
| | | | | |
1 VDTKDLENYY YHQRQRGHST RGLSDDNIGL LDYAFVKLTM DNDIFTETFF NTYKSFTTTT 60
61 TVLENMAKRY VGAKSCSVSI SKIL
|
| Detection Method: | |
| Confidence: | 22.853872 |
| Match: | PF00618 |
| Description: | Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1189-1614] |
1 11 21 31 41 51
| | | | | |
1 DRSDDSKMKI NEDTNLVSSS LYDQNFPVWD MKVTDDENIN LIYMAKIQIG AAEAILHLVK 60
61 NHYSDFTDDL CNNSTLLDII KIMEQEVSTE WPTRIANSKL QKSLPENFVI ETENLLTTLT 120
121 DLFHGIKSAY QKQLYRPIGV NRTQKRITDI LNSFNTFSFT DLNNIIDDPS FSDDMIRSFQ 180
181 KLHSTNYEDI LEWIYQLDNF ISKKFNLVSK KDWIVLFQEL ELLSKESLVS FFNYPLHFKS 240
241 SKLINPGYLQ LHEFEISNLF TWISTLILKD DNGTESLFFE KLPQSIKLLI KLHTSLTTFF 300
301 VMEISNVNKS SSERLTTCKV ILQILNYIRW KNGSLDLFDS EEDESPHAIC PHIPAFIETA 360
361 IAHAIISPES RNYELSWIKA SEKLSDPTKG TQNLRSISNV LEKIDDIHIK RFIEIDDVFS 420
421 KNCKNL
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1615-1914] |
1 11 21 31 41 51
| | | | | |
1 CPCPGWFISR LLEISQFVPN MSITNSKLIN FDKRRFVNNI ISNVLDLIPN EREFPLDIEM 60
61 SDENPSKRTT FGRILFNNFE DVNKVYRKKT KKVSESEAIS ERFQEQGVFN EILVNEIEKI 120
121 KREARKLEVL LDQEKILKNS AALHQAVPKK NRKSVIISGT HSDNDHSYNI NKNTGQTPSL 180
181 GSVMESNNSA RNRRDSRASF STNRSSVVSN SSHNGVSKKI GGFFRRPFSI GGFNTSSSNY 240
241 SLNSILSQEV SSNKSILPSI LPEVDSMQLH DLKPSYSLKT FEIKSIMEII NHRNIPAYYY 300
301
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1915-2051] |
1 11 21 31 41 51
| | | | | |
1 AFKIVMQNGH EYLIQTASSS DLTEWIKMIK ASKRFSFHSK KYKGKTHNKI FGVPLEDVCE 60
61 RENTLIPTIV VKLLEEIELR GLDEVGLYRI PGSIGSINAL KNAFDEEGAT DNSFTLEDDR 120
121 WFEVNAIAGC FKMYLRE
|
| Detection Method: | |
| Confidence: | 124.211549 |
| Match: | 1f7cA_ |
| Description: | Graf |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [2052-2167] |
1 11 21 31 41 51
| | | | | |
1 LPDSLFSHAM VNDFTDLAIK YKAHAMVNEE YKRMMNELLQ KLPTCYYQTL KRIVFHLNKV 60
61 HQHVVNNKMD ASNLAIVFSM SFINQEDLAN SMGSRLGAVQ TILQDFIKNP NDYFKQ
|
| Detection Method: | |
| Confidence: | 124.211549 |
| Match: | 1f7cA_ |
| Description: | Graf |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1873-2167] |
1 11 21 31 41 51
| | | | | |
1 SILPEVDSMQ LHDLKPSYSL KTFEIKSIME IINHRNIPAY YYAFKIVMQN GHEYLIQTAS 60
61 SSDLTEWIKM IKASKRFSFH SKKYKGKTHN KIFGVPLEDV CERENTLIPT IVVKLLEEIE 120
121 LRGLDEVGLY RIPGSIGSIN ALKNAFDEEG ATDNSFTLED DRWFEVNAIA GCFKMYLREL 180
181 PDSLFSHAMV NDFTDLAIKY KAHAMVNEEY KRMMNELLQK LPTCYYQTLK RIVFHLNKVH 240
241 QHVVNNKMDA SNLAIVFSMS FINQEDLANS MGSRLGAVQT ILQDFIKNPN DYFKQ
|
| Detection Method: | |
| Confidence: | 71.30103 |
| Match: | 1xa6A |
| Description: | Crystal Structure of the Human Beta2-Chimaerin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| Rho GTPase activator activity | 4.58620967349979 | bayes_pls_golite062009 |
| Rac GTPase activator activity | 3.29568423512865 | bayes_pls_golite062009 |
| GTPase regulator activity | 2.70614727793157 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 2.68579854252375 | bayes_pls_golite062009 |
| binding | 2.36195429973813 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 2.06038764955701 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.9750017471254 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.95738547986197 | bayes_pls_golite062009 |
| transcription regulator activity | 1.8643617990865 | bayes_pls_golite062009 |
| protein binding | 1.29100556128076 | bayes_pls_golite062009 |
| nucleic acid binding | 1.23177892465869 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.2233434243135 | bayes_pls_golite062009 |
| DNA binding | 1.13840440643872 | bayes_pls_golite062009 |
| Ras GTPase activator activity | 1.09070479183477 | bayes_pls_golite062009 |
| actin binding | 1.02058870188398 | bayes_pls_golite062009 |
| Ras guanyl-nucleotide exchange factor activity | 0.958295643211986 | bayes_pls_golite062009 |
| GTPase activator activity | 0.717730683557543 | bayes_pls_golite062009 |
| tubulin binding | 0.607820429385701 | bayes_pls_golite062009 |
| transcription factor activity | 0.570759131322384 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.31992783387711 | bayes_pls_golite062009 |
| enzyme activator activity | 0.298334474872045 | bayes_pls_golite062009 |
| catalytic activity | 0.194464246602439 | bayes_pls_golite062009 |
| motor activity | 0.17371606412934 | bayes_pls_golite062009 |
| microfilament motor activity | 0.0044514849726196 | bayes_pls_golite062009 |
