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Protein Overview: PSK2

General Information:
Name(s) found: PSK2 / YOL045W [SGD]
Description(s) found:
Found 23 descriptions.
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  • One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1101 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: hexose metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYPVSAAAP ADISYSKNTP LVGLSKPPCL YQHASSSVDS FSSTFSDDDR SDLVAVPNES  60
   61 PHAFSYNPIS PNSLGVRLTI LRRSLEIMVN SPDILHELKK KAPVIAYPPS LRHTRNLTET 120
  121 ATLSASRDPL NGSLISPLVS NMPSPASRPV IQRATSLMVL PDNDTASKLN PAKSELENLL 180
  181 FLLNLALENN SFERASDLHM LSLLNIKKIN FDSDIQKSET LKKVLLDSLA EPFFENYKKF 240
  241 PHKDLGSKSQ YNEYEEKHDD IVSLADIKPQ QDYSRILHPF TSAKNSGPEA IFTCSQQYPW 300
  301 NFKAANDLAC LTFGISKNVI KALTLLDLIH TDSRNFVLEK IMNAEDDNQE IVFTGETIPI 360
  361 VQPNSTSNNN VPNLIWASLW AKRKNGLLVC VFEKTPCDYI DVMLNLRDFS VDSIIDTTHF 420
  421 LENFDKKKQQ ESTSPMTEKK TVKFANEIHD IGSVSHSLSK LIDDVRFGKV FSADDDLLPL 480
  481 SIRVANHVNE ERYFTLNCLS ENIPCAVTTS VLENEIKLKI HSLPYQAGLF IVDSHTLSLL 540
  541 SFNKSVAKNM FGLRLHELAG SSVTKLVPSL ADMISYINKT YPMLNITLPE NKGLVLTEHF 600
  601 FRKIEAEMHH DKDSFYTSIG LDGCHKDGNL IKVDVQLRVL NTNAVLLWIT HSRDVVIENY 660
  661 TTVPSQLPML KENEIDVVGS RGSSSASSKK SSEKIPVNTL KAMADLSISS AETISNSDDE 720
  721 VDLNQVNEKL RETSCGKVRG IESNDNNNYD DDMTMVDDPE LKHKIELTKM YTQDKSKFVK 780
  781 DDNFKVDEKF IMRIIEPING EEIKKETNEL DKRNSTLKAT YLTTPEANIG SQKRIKKFSD 840
  841 FTILQVMGEG AYGKVNLCIH NREHYIVVIK MIFKERILVD TWVRDRKLGT IPSEIQIMAT 900
  901 LNKNSQENIL KLLDFFEDDD YYYIETPVHG ETGSIDLFDV IEFKKDMVEH EAKLVFKQVV 960
  961 ASIKHLHDQG IVHRDIKDEN VIVDSHGFVK LIDFGSAAYI KSGPFDVFVG TMDYAAPEVL1020
 1021 GGSSYKGKPQ DIWALGVLLY TIIYKENPYY NIDEILEGEL RFDKSEHVSE ECISLIKRIL1080
 1081 TREVDKRPTI DEIYEDKWLK I

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PSK1 PSK2
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Ho Y, et al. (2002) FUN30 GPH1 HPR1 PSK1 PSK2 RPN1 RVB1 SET1 SFP1 SGS1 SUV3 SWD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PSK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208] MSA 1.002935 View MSA. No confident structure predictions are available.
    2 View Details [209..287] deduced N/A No confident structure predictions are available.
    3 View Details [288..433] ORFEUS 12.82 N-terminal PAS domain of Pas kinase
    4 View Details [434..627] deduced N/A No confident structure predictions are available.
    5 View Details [628..813] PSI-BLAST 23.0 C2 domain from protein kinase c (alpha)
    6 View Details [814..896]
    [912..931]    		 PSI-BLAST 318.228787 cAMP-dependent PK, catalytic subunit
    7 View Details [897..911]
    [932..1101]    		 PSI-BLAST 318.228787 cAMP-dependent PK, catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.27604928641749 bayes_pls_golite062009
  • DNA binding
    		•  3.83861939247274 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.43738039086015 bayes_pls_golite062009
  • transcription factor activity
    		•  3.18442852449976 bayes_pls_golite062009
  • binding
    		•  3.0194696248926 bayes_pls_golite062009
  • transcription factor binding
    		•  2.22314179303094 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.13819142609078 bayes_pls_golite062009
  • transcription activator activity
    		•  1.8593473738006 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.79890159148529 bayes_pls_golite062009
  • kinase activity
    		•  1.74754238129423 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64278494326255 bayes_pls_golite062009
  • protein binding
    		•  1.60673447924806 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.58952910634461 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.54935001412565 bayes_pls_golite062009
  • transporter activity
    		•  1.29285553966065 bayes_pls_golite062009
  • transferase activity
    		•  1.23751181381315 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.12976327507582 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.06445298547053 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.03821974317465 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.01758076208626 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.934727986222767 bayes_pls_golite062009
  • enzyme binding
    		•  0.902069383016175 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.872276459885952 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.865848090169615 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.836285382533069 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.832216703182726 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.818533732821494 bayes_pls_golite062009
  • cation channel activity
    		•  0.764382438962433 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.724783984982155 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.724434551854819 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.701205842109604 bayes_pls_golite062009
  • gated channel activity
    		•  0.678642047604949 bayes_pls_golite062009
  • ion channel activity
    		•  0.642071926991696 bayes_pls_golite062009
  • potassium channel activity
    		•  0.634191734666345 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.614755150740891 bayes_pls_golite062009
  • histone acetyltransferase binding
    		•  0.609670492126344 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.603095294300374 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.593195618191767 bayes_pls_golite062009
  • channel activity
    		•  0.593195618191767 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.533026069704694 bayes_pls_golite062009
  • receptor binding
    		•  0.47195382831751 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.119454387636252 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.104316215089923 bayes_pls_golite062009
    5
    Term Confidence Notes
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • phospholipid binding
    		•  0.98776359922762 bayes_pls_golite062009
  • transporter activity
    		•  0.698425581375283 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  0.688833750465289 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.172018617171784 bayes_pls_golite062009
  • SNARE binding
    		•  0.102282725391911 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle