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Protein Overview: FUN30

General Information:
Name(s) found: FUN30 / YAL019W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1131 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: chromosome organization [IGI]
    chromatin silencing at rDNA [IMP]
    chromatin silencing at silent mating-type cassette [IMP][IPI]
    chromatin silencing at telomere [IMP]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSHSNDED DVVQVPETSS PTKVASSSPL KPTSPTVPDA SVASLRSRFT FKPSDPSEGA  60
   61 HTSKPLPSGS PEVALVNLAR EFPDFSQTLV QAVFKSNSFN LQSARERLTR LRQQRQNWTW 120
  121 NKNASPKKSE TPPPVKKSLP LANTGRLSSI HGNINNKSSK ITVAKQKTSI FDRYSNVINQ 180
  181 KQYTFELPTN LNIDSEALSK LPVNYNKKRR LVRADQHPIG KSYESSATQL GSAREKLLAN 240
  241 RKYGRHANDN DEEEEESMMT DDDDASGDDY TESTPQINLD EQVLQFINDS DIVDLSDLSD 300
  301 TTMHKAQLIA SHRPYSSLNA FVNTNFNDKD TEENASNKRK RRAAASANES ERLLDKITQS 360
  361 IRGYNAIESV IKKCSSYGDL VTSQMKKWGV QVEGDNSELD LMNLGEDDDD DNDDGNNDNN 420
  421 NSNNNNTAGA DATSKEKEDT KAVVEGFDET SAEPTPAPAP APVERETKRI RNTTKPKVVE 480
  481 DEDDDVDLEA IDDELPQSEH EDDDYEEEDE DYNDEEEDVE YDDGDDDDDD DDEFVATRKN 540
  541 THVISTTSRN GRKPIVKFFK GKPRLLSPEI SLKDYQQTGI NWLNLLYQNK MSCILADDMG 600
  601 LGKTCQVISF FAYLKQINEP GPHLVVVPSS TLENWLREFQ KFAPALKIEP YYGSLQEREE 660
  661 LRDILERNAG KYDVIVTTYN LAAGNKYDVS FLKNRNFNVV VYDEGHMLKN STSERFAKLM 720
  721 KIRANFRLLL TGTPLQNNLK ELMSLLEFIM PNLFISKKES FDAIFKQRAK TTDDNKNHNP 780
  781 LLAQEAITRA KTMMKPFILR RRKDQVLKHL PPKHTHIQYC ELNAIQKKIY DKEIQIVLEH 840
  841 KRMIKDGELP KDAKEKSKLQ SSSSKNLIMA LRKASLHPLL FRNIYNDKII TKMSDAILDE 900
  901 PAYAENGNKE YIKEDMSYMT DFELHKLCCN FPNTLSKYQL HNDEWMQSGK IDALKKLLKT 960
  961 IIVDKQEKVL IFSLFTQVLD ILEMVLSTLD YKFLRLDGST QVNDRQLLID KFYEDKDIPI1020
 1021 FILSTKAGGF GINLVCANNV IIFDQSFNPH DDRQAADRAH RVGQTKEVNI TTLITKDSIE1080
 1081 EKIHQLAKNK LALDSYISED KKSQDVLESK VSDMLEDIIY DENSKPKGTK E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AAT2 FUN30
    View Details Gavin AC, et al. (2002) FUN30 MIS1 TEL1
    View Details Ho Y, et al. (2002) FUN30 PSK1 PSK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FUN30 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] MSA 82.329997 View MSA. No confident structure predictions are available.
    2 View Details [216..312] PSI-BLAST 5.522879 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    3 View Details [313..365]
    [452..521]    		 PSI-BLAST 5.522879 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [366..451]
    [522..771]    		 PSI-BLAST 5.522879 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    5 View Details [772..852] deduced N/A No confident structure predictions are available.
    6 View Details [853..1065] PSI-BLAST 7.0 Putative DEAD box RNA helicase
    7 View Details [1066..1131] PSI-BLAST 5.0 Nucleotide excision repair enzyme UvrB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  3.89165617439497 bayes_pls_golite062009
  • DNA binding
    		•  3.38561002225202 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.99888727194073 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.93712042261633 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.43759174701552 bayes_pls_golite062009
  • structural molecule activity
    		•  2.08258913217268 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69669059514663 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.96756670903925 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889401463702631 bayes_pls_golite062009
  • transcription factor activity
    		•  0.859071050218437 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.844320909398101 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.77755643935497 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.702449673647117 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.52700145953711 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • RNA binding
    		•  0.18502033889261 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • nuclease activity
    		•  0.111225677144242 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.108195560803799 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.02893949194171 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.97909493766908 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.95844964816653 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.95658009428828 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • ATPase activity
    		•  1.42257610975945 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.02424782546779 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • hydrolase activity
    		•  0.98565595572967 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.95986988363392 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.94128341275411 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.732723553251109 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • transcription activator activity
    		•  0.537911793669378 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.407727781673696 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.396187998943318 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.38363601832205 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.144154288308693 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • motor activity
    		•  0.0492172159259601 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle