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View Structure Prediction Details

Protein: FUN30
Organism: Saccharomyces cerevisiae
Length: 1131 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUN30.

Description E-value Query
Range		 Subject
Range
FUN30 - Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Sn...
FUN30_YEAST - ATP-dependent helicase FUN30 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUN30 PE=1 ...
 0.0 [1..1131] [1..1131]
gi|6329728 - gi|6329728|dbj|BAA86436.1| KIAA1122 protein [Homo sapiens]
 0.0 [87..1116] [10..1043]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [56..1116] [89..1131]
gi|45384078, gi|... - gi|996020|emb|CAA62832.1| BRM protein [Gallus gallus], gi|45384078|ref|NP_990470.1| SWI/SNF related,...
 0.0 [30..1119] [94..1217]
kis-PA - The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a prot...
 0.0 [91..1131] [1504..2545]
fft2 - fun thirty related protein Fft2
FFT2_SCHPO - ATP-dependent helicase fft2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fft2 PE=1 SV=1
 0.0 [19..1125] [29..1096]

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Predicted Domain #1
Region A:
Residues: [1-215] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSHSNDED DVVQVPETSS PTKVASSSPL KPTSPTVPDA SVASLRSRFT FKPSDPSEGA  60
   61 HTSKPLPSGS PEVALVNLAR EFPDFSQTLV QAVFKSNSFN LQSARERLTR LRQQRQNWTW 120
  121 NKNASPKKSE TPPPVKKSLP LANTGRLSSI HGNINNKSSK ITVAKQKTSI FDRYSNVINQ 180
  181 KQYTFELPTN LNIDSEALSK LPVNYNKKRR LVRAD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-312] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHPIGKSYES SATQLGSARE KLLANRKYGR HANDNDEEEE ESMMTDDDDA SGDDYTESTP  60
   61 QINLDEQVLQ FINDSDIVDL SDLSDTTMHK AQLIASH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [313-365] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPYSSLNAFV NTNFNDKDTE ENASNKRKRR AAASANESER LLDKITQSIR GYN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [452-521] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEPTPAPAPA PVERETKRIR NTTKPKVVED EDDDVDLEAI DDELPQSEHE DDDYEEEDED  60
   61 YNDEEEDVEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.89165617439497 bayes_pls_golite062009
DNA binding 3.38561002225202 bayes_pls_golite062009
structure-specific DNA binding 2.99888727194073 bayes_pls_golite062009
single-stranded DNA binding 2.93712042261633 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
structural constituent of ribosome 2.43759174701552 bayes_pls_golite062009
structural molecule activity 2.08258913217268 bayes_pls_golite062009
transcription regulator activity 1.69669059514663 bayes_pls_golite062009
translation regulator activity 1.46320772716954 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.40718318783582 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.35850109411274 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.35845277283398 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.35845277283398 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
translation initiation factor activity 0.96756670903925 bayes_pls_golite062009
transcription activator activity 0.889401463702631 bayes_pls_golite062009
transcription factor activity 0.859071050218437 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.844320909398101 bayes_pls_golite062009
sequence-specific DNA binding 0.77755643935497 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
telomeric DNA binding 0.52700145953711 bayes_pls_golite062009
ligase activity 0.346041081217685 bayes_pls_golite062009
RNA binding 0.18502033889261 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.151650064901878 bayes_pls_golite062009
nuclease activity 0.111225677144242 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.108195560803799 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [366-451] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIESVIKKCS SYGDLVTSQM KKWGVQVEGD NSELDLMNLG EDDDDDNDDG NNDNNNSNNN  60
   61 NTAGADATSK EKEDTKAVVE GFDETS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [522-771] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDGDDDDDDD DEFVATRKNT HVISTTSRNG RKPIVKFFKG KPRLLSPEIS LKDYQQTGIN  60
   61 WLNLLYQNKM SCILADDMGL GKTCQVISFF AYLKQINEPG PHLVVVPSST LENWLREFQK 120
  121 FAPALKIEPY YGSLQEREEL RDILERNAGK YDVIVTTYNL AAGNKYDVSF LKNRNFNVVV 180
  181 YDEGHMLKNS TSERFAKLMK IRANFRLLLT GTPLQNNLKE LMSLLEFIMP NLFISKKESF 240
  241 DAIFKQRAKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.02893949194171 bayes_pls_golite062009
pyrophosphatase activity 1.97909493766908 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.95844964816653 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.95658009428828 bayes_pls_golite062009
DNA binding 1.7904783386531 bayes_pls_golite062009
transcription regulator activity 1.68903321260301 bayes_pls_golite062009
ATPase activity 1.42257610975945 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
RNA helicase activity 1.02424782546779 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
hydrolase activity 0.98565595572967 bayes_pls_golite062009
RNA-dependent ATPase activity 0.95986988363392 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.94128341275411 bayes_pls_golite062009
ATPase activity, coupled 0.732723553251109 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
purine nucleotide binding 0.725611289205392 bayes_pls_golite062009
structure-specific DNA binding 0.720649395550746 bayes_pls_golite062009
nucleotide binding 0.717697610309727 bayes_pls_golite062009
purine ribonucleotide binding 0.713814218071151 bayes_pls_golite062009
ribonucleotide binding 0.713752628021599 bayes_pls_golite062009
transcription factor activity 0.603758349693077 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
double-stranded DNA binding 0.58862275163252 bayes_pls_golite062009
transcription activator activity 0.537911793669378 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.407727781673696 bayes_pls_golite062009
structural constituent of ribosome 0.396187998943318 bayes_pls_golite062009
microtubule motor activity 0.38363601832205 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.22150712609541 bayes_pls_golite062009
ATP binding 0.19169045543599 bayes_pls_golite062009
adenyl ribonucleotide binding 0.165732470448462 bayes_pls_golite062009
adenyl nucleotide binding 0.162060759063149 bayes_pls_golite062009
substrate-specific transporter activity 0.144154288308693 bayes_pls_golite062009
active transmembrane transporter activity 0.114463153989353 bayes_pls_golite062009
motor activity 0.0492172159259601 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [772-852] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDDNKNHNPL LAQEAITRAK TMMKPFILRR RKDQVLKHLP PKHTHIQYCE LNAIQKKIYD  60
   61 KEIQIVLEHK RMIKDGELPK D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [853-1065] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKEKSKLQSS SSKNLIMALR KASLHPLLFR NIYNDKIITK MSDAILDEPA YAENGNKEYI  60
   61 KEDMSYMTDF ELHKLCCNFP NTLSKYQLHN DEWMQSGKID ALKKLLKTII VDKQEKVLIF 120
  121 SLFTQVLDIL EMVLSTLDYK FLRLDGSTQV NDRQLLIDKF YEDKDIPIFI LSTKAGGFGI 180
  181 NLVCANNVII FDQSFNPHDD RQAADRAHRV GQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1066-1131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVNITTLIT KDSIEEKIHQ LAKNKLALDS YISEDKKSQD VLESKVSDML EDIIYDENSK  60
   61 PKGTKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1d9xA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle