YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: PKH1

General Information:
Name(s) found: PKH1 / YDR490C [SGD]
Description(s) found:
Found 29 descriptions.
SHOW ALL
  • Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 766 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: MAPKKK cascade involved in cell wall biogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNRSLTEAD HALLSKPLVP TSAEHTQTQE YPRPFVDGSN SQSGSELQAS PQGQFGEKAL  60
   61 TSTNRFIPLA NDDPGMQHEM GLDPSMRRRR EEWAERGAAK IVKDVVDPAT GELTKHVVKM 120
  121 GIKDFKFGEQ LGDGSYSSVV LATARDSGKK YAVKVLSKEY LIRQKKVKYV TVEKLALQKL 180
  181 NGTKGIFKLF FTFQDEASLY FLLEYAPHGD FLGLIKKYGS LNETCARYYA SQIIDAVDSL 240
  241 HNIGIIHRDI KPENILLDKN MKVKLTDFGT AKILPEEPSN TADGKPYFDL YAKSKSFVGT 300
  301 AEYVSPELLN DNYTDSRCDI WAFGCILYQM LAGKPPFKAA NEYLTFQKVM KIQYAFTAGF 360
  361 PQIVKDLVKK LLVRDPNDRL TIKQIKAHLF FHEVNFEDGS VWDDNPPEIQ PYKINAEAMK 420
  421 PLQKVSESDT TVKMANLQLA GNGHADTPLQ APAATSQEHS VISMTAATAA FNKDYTSQPK 480
  481 LGSKSSTSVR SASNNTDREV IQKKVSKNRA SVSSPSISTT SRGKDNRSRS SDAFWSRYLQ 540
  541 NMDERVLLMK EVALSTRNLE DSPVGLENVA LDYKNPLDIE PPTDSAGKFY KKMFLITNLG 600
  601 RALVFVKRRS LSMWEEQEFE LQFELELNDV EKIRFISDQV LEIDGSRTIF IGCKERAVLM 660
  661 KLWKLIHNGM TAKPKVVSPK SDHKMFDKFI LQKRQNTKKK NQAPPVPQSN RLINGLPDRC 720
  721 ILKTPEEGAL HTKRPTSLQT RSSSNYSKLL ARSTQMRKNM TRTDEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LSP1 PIL1 PKH1
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Ho Y, et al. (2002) LSP1 PIL1 PKH1 TPK3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..174]
    [189..205]
    [412..483]    		 PSI-BLAST 571.9794 cAMP-dependent PK, catalytic subunit
    3 View Details [175..188]
    [206..411]    		 PSI-BLAST 571.9794 cAMP-dependent PK, catalytic subunit
    4 View Details [484..696] PSI-BLAST 4.0 Heavy meromyosin subfragment
    5 View Details [697..766] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle