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View Structure Prediction Details

Protein: PKH1
Organism: Saccharomyces cerevisiae
Length: 766 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PKH1.

Description E-value Query
Range
Subject
Range
PKH1 - Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls en...
PKH1_YEAST - Serine/threonine-protein kinase PKH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKH...
0.0 [1..766] [1..766]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [16..647] [2..585]
ROCK2_MOUSE - Rho-associated protein kinase 2 OS=Mus musculus GN=Rock2 PE=1 SV=1
0.0 [16..647] [2..585]
gi|148224746, gi... - gi|2982220|gb|AAC06351.1| Rho-associated kinase alpha [Xenopus laevis], gi|148224746|ref|NP_00108094...
0.0 [38..648] [10..574]
gi|16648134 - gi|16648134|gb|AAL25332.1| GH13631p [Drosophila melanogaster]
0.0 [5..471] [114..547]
ROCK1_RAT - Rho-associated protein kinase 1 OS=Rattus norvegicus GN=Rock1 PE=1 SV=1
0.0 [50..648] [20..569]
ROCK1 - Rho-associated, coiled-coil containing protein kinase 1
0.0 [50..648] [20..569]
ROCK1_RABIT - Rho-associated protein kinase 1 OS=Oryctolagus cuniculus GN=ROCK1 PE=1 SV=1
0.0 [50..648] [20..569]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNRSLTEAD HALLSKPLVP TSAEHTQTQE YPRPFVDGSN SQSGSELQAS PQGQFGEKAL  60
   61 TSTNRFIPLA ND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPGMQHEMGL DPSMRRRREE WAERGAAKIV KDVVDPATGE LTKHVVKMGI KDFKFGEQLG  60
   61 DGSYSSVVLA TARDSGKKYA VKVLSKEYLI RQKKVKYVTV EK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [189-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFFTFQDEAS LYFLLEY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [412-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKINAEAMKP LQKVSESDTT VKMANLQLAG NGHADTPLQA PAATSQEHSV ISMTAATAAF  60
   61 NKDYTSQPKL GS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 571.9794
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [175-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LALQKLNGTK GIFK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [206-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APHGDFLGLI KKYGSLNETC ARYYASQIID AVDSLHNIGI IHRDIKPENI LLDKNMKVKL  60
   61 TDFGTAKILP EEPSNTADGK PYFDLYAKSK SFVGTAEYVS PELLNDNYTD SRCDIWAFGC 120
  121 ILYQMLAGKP PFKAANEYLT FQKVMKIQYA FTAGFPQIVK DLVKKLLVRD PNDRLTIKQI 180
  181 KAHLFFHEVN FEDGSVWDDN PPEIQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 571.9794
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [484-696]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSSTSVRSAS NNTDREVIQK KVSKNRASVS SPSISTTSRG KDNRSRSSDA FWSRYLQNMD  60
   61 ERVLLMKEVA LSTRNLEDSP VGLENVALDY KNPLDIEPPT DSAGKFYKKM FLITNLGRAL 120
  121 VFVKRRSLSM WEEQEFELQF ELELNDVEKI RFISDQVLEI DGSRTIFIGC KERAVLMKLW 180
  181 KLIHNGMTAK PKVVSPKSDH KMFDKFILQK RQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [697-766]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKKNQAPPV PQSNRLINGL PDRCILKTPE EGALHTKRPT SLQTRSSSNY SKLLARSTQM  60
   61 RKNMTRTDEK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle