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Protein Overview: YLR422W

General Information:
Name(s) found: YLR422W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1932 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQDSQRWL PTDRLIYGVL VKSFLPLQRY PELVYENSNY ANVYVGAEVY VFEESVDKKW  60
   61 CRAYQCLRPF PEEFISNMNS ANDVLPDVKP KVVIFPRKYV HFEAEKAVST MPFFKAPSAE 120
  121 DFKPLISKEC ESRSFCDSLY VSSTDDISTG KPRKTPRPPF PFFRYQKRSF KDEMGPILSL 180
  181 ISSHVYSMYS IGEFSIYRKM IKLYYDLDTI RFRLSMNLTT EAEKINLIRA ATSLRTKIAK 240
  241 FLSSTYRKNK LIANSTPRNP DPYGFEGIFA RDIDTGELLS YEIDKLRTLV SSSMLCGLTN 300
  301 NFPTVPVVES DDESSSNGLF GTVRSSILVN LKDLAWDPSI SDPKYQDLSI CVYLRTKDEV 360
  361 LTESFTMTKS SNMESALDEI PAMLFKNILE TIVHKNKVYL VVVLKETIAI TTETAPEISS 420
  421 YNISTEESSS HSPFSPFNSS TENKIDHVKK GLAAGVINIS PVFKFYNGLS VANKAQRFNL 480
  481 YLYSSDSSDS QNFNSSKDAD LGWGGLINKI IKDSSEGVSV NPRAVSLSVT VKEIIGKQEA 540
  541 EKVLSTSLVP IRSIPTYFYD TMFSQAERIY LNLGRVSLYG LPAADTNIEN VTVQISCRNK 600
  601 AVKFCKNKLE ERSGDWKFVS VRPNESIGES IRIEGVENMN EDETLRVLVY LNGFLMAKSN 660
  661 IHIKKKNEII EYRKGTVFQI MSSKSVPLIH LELEASYFGR RYNINPAITN FLVLQTKNVE 720
  721 FDQQLKEHYS VTLKQLNNVS FKDLLKHFDT ILAHYLLLLE SVNEATDKKG PSSSLPNIVF 780
  781 SEFVKFLNLM LTHQENSRYW FNRLYKKVMS KELECPNVAP ILIKHMTTIF DRSHSSWTRT 840
  841 GTAICRTILY IIVLAIGSSH SDEMPNFSHF FRSLHKFLML ADEPIMADQI LLIESIPSML 900
  901 ETMTNHCKVE DLVRFAIGLF ECCQEKEMNQ KMYSRPLSVR EEEYLNTKFN CLLKLINKKV 960
  961 LQNYLTNTES VDKLRLQFLS KTLEWLLTPY TPGDDKCFHV ESLRLVNSVF ITIIEDYKFD1020
 1021 MLQRNLIRLL PYLCKSFVHL RRYCKKARLM RPRRVFTMLF PREIPCNYIP VDSIVNDEVV1080
 1081 VEVLLELAII ICEITKIASS RFPSYQSFSE IINLCDKDTL FQSNFYSRQI TNENVYTITK1140
 1141 TVFLFFKQDW FPGMKWLGVS ALLGRSSLIL LSLCKDYIIE NNSPSPSKES EKRVDMRLWA1200
 1201 EYVKVILLVS NHKSASLTKL AITPRKAVYL ISGDLKKISA YILNECWDAL ATGHYNITYA1260
 1261 KKYGLGALSD CQFELFVHNQ FLIREIFIFA FHRHIDATRI CCKILWGLGL NFWRIFGSLQ1320
 1321 PAVNACIPEL FSAYQIGKLR LNDYELERFV SCLFFMMHVP DSDTFFPACM DFLRDLLGFL1380
 1381 HIVNEIYKIP NQEEFDDDRT ARHIEMFEYL LEANRPELFH KMIYDLFIHF IQKKDFVQAA1440
 1441 LSLELLAGTY AWDSNDTLEA ISFPPLPEQS SFERKEYLLK ESARNFSRGQ KPEKALAVYK1500
 1501 DLIKAYDEIN YDLNGLAFVH DQIAGIYTRL QSIDRLVPTY FKVSFMGFGF PKSLRNKSFV1560
 1561 FEGLPFEHIT SMHDRLLRSY HGSNIVHSQE EVDMLLMNPP MGKYIHVASV EPCLSISDNY1620
 1621 NSSDKKSSIN NKVRMYIENR DLRTFSNSRR LPGAKGVTDL WVEEYTYHTM NTFPTLMNRS1680
 1681 EIVKVTKSKL SPLENAIRSL QVKIQELYGL ENMCNKTLKD HGDVNDLFTE LSTNITGTIS1740
 1741 APVNGGISQY KAFLEPSTSK QFSTDDLGRL TLAFDELVAV LGRCLTLHAE LLPSKDLKPS1800
 1801 HDLLVRLFEE NFAEEIERYS RTLSEANRSR NNMITARIIS HKNPNKKASF SGRDHHTSGS1860
 1861 NHSQFVLEHS DSFGPNSLLF GKYLTRTLSH SSTTSSLDKS GIVSGTSSTF LAGSQPNTNT1920
 1921 DSQHKHDYSH SG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARO1 CKB2 CUE5 LSB3 UBP15 YFR024C YJL045W YLR422W YME2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YLR422W Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1253] deduced N/A No confident structure predictions are available.
    2 View Details [1254..1856] MSA 9.037877 View MSA. No confident structure predictions are available.
    3 View Details [1857..1932] deduced N/A No confident structure predictions are available.
    4 View Details [435..498] deduced N/A No confident structure predictions are available.
    5 View Details [499..586] deduced N/A No confident structure predictions are available.
    6 View Details [587..770] deduced N/A No confident structure predictions are available.
    7 View Details [771..987] deduced N/A No confident structure predictions are available.
    8 View Details [988..1101] deduced N/A No confident structure predictions are available.
    9 View Details [1102..1165] MSA 2.065996 View MSA. No confident structure predictions are available.
    10 View Details [1166..1269] MSA 1.068988 View MSA. No confident structure predictions are available.
    11 View Details [1270..1307] MSA 1.091996 View MSA. No confident structure predictions are available.
    12 View Details [1308..1395] MSA 2.106986 View MSA. No confident structure predictions are available.
    13 View Details [1396..1468] MSA 1.125982 View MSA. No confident structure predictions are available.
    14 View Details [1469..1533] MSA 2.127994 View MSA. No confident structure predictions are available.
    15 View Details [1534..1626] MSA 2.131985 View MSA. No confident structure predictions are available.
    16 View Details [1627..1691] deduced N/A No confident structure predictions are available.
    17 View Details [1692..1846] MSA 8.131981 View MSA. No confident structure predictions are available.
    18 View Details [1847..1932] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.52511960414654 bayes_pls_golite062009
  • binding
    		•  1.26123458430912 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.
    15 No functions predicted.
    16 No functions predicted.
    17 No functions predicted.
    18 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle