YRC Public Data Repository - Protein Structure Prediction

Protein:	ARO1
Organism:	Saccharomyces cerevisiae
Length:	1588 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARO1.

Description	E-value	Query Range	Subject Range
aro1 - pentafunctional aromatic polypeptide Aro1 ARO1_SCHPO - Pentafunctional AROM polypeptide OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=aro1 PE=3...	0.0	[2..1587]	[5..1573]
ARO1_YEAST - Pentafunctional AROM polypeptide OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO1 PE... ARO1 - Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which i...	0.0	[1..1588]	[1..1588]
ARO1_PNECA - Pentafunctional AROM polypeptide OS=Pneumocystis carinii GN=arom PE=3 SV=1	0.0	[1..1586]	[1..1577]
ARO1_EMENI - Pentafunctional AROM polypeptide OS=Emericella nidulans GN=aroMA PE=1 SV=2	0.0	[1..1564]	[1..1559]
ARO1_NEUCR - Pentafunctional AROM polypeptide OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 /... gi\|28917040, gi\|... - gi\|32415183\|ref\|XP_328071.1\| hypothetical protein [Neurospora crassa], gi\|28917040\|gb\|EAA26764.1\| pe...	0.0	[1..1576]	[5..1551]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..1567]	[1..1562]

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Predicted Domain #1

Region A:
Residues: [1-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQLAKVPIL GNDIIHVGYN IHDHLVETII KHCPSSTYVI CNDTNLSKVP YYQQLVLEFK  60
   61 ASLPEGSRLL TYVVKPGETS KSRETKAQLE DYLLVEGCTR DTVMVAIGGG VIGDMIGFVA 120
  121 STFMRGVRVV QVPTSLLAMV DSSIGGKTAI DTPLGKNFIG AFWQPKFVLV DIKWLET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1193.0
Match:	1dqsA_
Description:	Dehydroquinate synthase, DHQS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-dehydroquinate synthase activity	2.66599995323323	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity	1.67555894260491	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.60362129760665	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	1.17319455535469	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.9498376010104	bayes_pls_golite062009
binding	0.269295154787597	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [178-188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKREFINGM A

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [204-267]

      1          11         21         31         41         51         
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    1 RLESNASLFL NVVNGAKNVK VTNQLTNEID EISNTDIEAM LDHTYKLVLE SIKVKAEVVS  60
   61 SDER

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1193.0
Match:	1dqsA_
Description:	Dehydroquinate synthase, DHQS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-phosphoshikimate 1-carboxyvinyltransferase activity	4.55308689407075	bayes_pls_golite062009
catalytic activity	2.54689525592227	bayes_pls_golite062009
transferase activity	2.40426218246544	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.71244782128226	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [189-203]

      1          11         21         31         41         51         
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    1 EVIKTACIWN ADEFT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [268-401]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESSLRNLLNF GHSIGHAYEA ILTPQALHGE CVSIGMVKEA ELSRYFGILS PTQVARLSKI  60
   61 LVAYGLPVSP DEKWFKELTL HKKTPLDILL KKMSIDKKNE GSKKKVVILE SIGKCYGDSA 120
  121 QFVSDEDLRF ILTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1193.0
Match:	1dqsA_
Description:	Dehydroquinate synthase, DHQS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.33437370519308	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.504749089115909	bayes_pls_golite062009
nucleotide binding	0.0579200404644161	bayes_pls_golite062009
purine nucleotide binding	0.0495693457499699	bayes_pls_golite062009
purine ribonucleotide binding	0.0346567694159108	bayes_pls_golite062009
ribonucleotide binding	0.0345962863831976	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [402-423]

      1          11         21         31         41         51         
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    1 ETLVYPFKDI PADQQKVVIP PG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [654-715]

      1          11         21         31         41         51         
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    1 SDASSATYPL AFAAMTGTTV TVPNIGFESL QGDARFARDV LKPMGCKITQ TATSTTVSGP  60
   61 PV

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [854-880]

      1          11         21         31         41         51         
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    1 TGKTWPGWWD VLHSELGAKL DGAEPLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	788.9897
Match:	1ln5A_
Description:	No description for 1ln5A_ was found.

Predicted Domain #5

Region A:
Residues: [424-653]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKSISNRALI LAALGEGQCK IKNLLHSDDT KHMLTAVHEL KGATISWEDN GETVVVEGHG  60
   61 GSTLSACADP LYLGNAGTAS RFLTSLAALV NSTSSQKYIV LTGNARMQQR PIAPLVDSLR 120
  121 ANGTKIEYLN NEGSLPIKVY TDSVFKGGRI ELAATVSSQY VSSILMCAPY AEEPVTLALV 180
  181 GGKPISKLYV DMTIKMMEKF GINVETSTTE PYTYYIPKGH YINPSEYVIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [716-853]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTLKPLKHVD MEPMTDAFLT ACVVAAISHD SDPNSANTTT IEGIANQRVK ECNRILAMAT  60
   61 ELAKFGVKTT ELPDGIQVHG LNSIKDLKVP SDSSGPVGVC TYDDHRVAMS FSLLAGMVNS 120
  121 QNERDEVANP VRILERHC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	788.9897
Match:	1ln5A_
Description:	No description for 1ln5A_ was found.

Predicted Domain #6

Region A:
Residues: [881-1057]

      1          11         21         31         41         51         
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    1 CTSKKNSKKS VVIIGMRAAG KTTISKWCAS ALGYKLVDLD ELFEQQHNNQ SVKQFVVENG  60
   61 WEKFREEETR IFKEVIQNYG DDGYVFSTGG GIVESAESRK ALKDFASSGG YVLHLHRDIE 120
  121 ETIVFLQSDP SRPAYVEEIR EVWNRREGWY KECSNFSFFA PHCSAEAEFQ ALRRSFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	166.69897
Match:	1shkA_
Description:	Shikimate kinase (AroK)
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [1058-1070]

      1          11         21         31         41         51         
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    1 KYIATITGVR EIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1196-1304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHHDFQGLYS WDDAEWENRF NQALTLDVDV VKFVGTAVNF EDNLRLEHFR DTHKNKPLIA  60
   61 VNMTSKGSIS RVLNNVLTPV TSDLLPNSAA PGQLTVAQIN KMYTSMGGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.07631
Match:	1qfeA_
Description:	Type I 3-dehydroquinate dehydratase
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [1071-1195]

      1          11         21         31         41         51         
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    1 IPSGRSAFVC LTFDDLTEQT ENLTPICYGC EAVEVRVDHL ANYSADFVSK QLSILRKATD  60
   61 SIPIIFTVRT MKQGGNFPDE EFKTLRELYD IALKNGVEFL DLELTLPTDI QYEVINKRGN 120
  121 TKIIG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.07631
Match:	1qfeA_
Description:	Type I 3-dehydroquinate dehydratase
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1305-1420]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPKELFVVGK PIGHSRSPIL HNTGYEILGL PHKFDKFETE SAQLVKEKLL DGNKNFGGAA  60
   61 VTIPLKLDIM QYMDELTDAA KVIGAVNTVI PLGNKKFKGD NTDWLGIRNA LINNGV

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	5.30103
Match:	PF01488
Description:	Shikimate / quinate 5-dehydrogenase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1421-1588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEYVGHTAGL VIGAGGTSRA ALYALHSLGC KKIFIINRTT SKLKPLIESL PSEFNIIGIE  60
   61 STKSIEEIKE HVGVAVSCVP ADKPLDDELL SKLERFLVKG AHAAFVPTLL EAAYKPSVTP 120
  121 VMTISQDKYQ WHVVPGSQML VHQGVAQFEK WTGFKGPFKA IFDAVTKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.221849
Match:	1gpjA_
Description:	Glutamyl tRNA-reductase dimerization domain; Glutamyl tRNA-reductase middle domain; Glutamyl tRNA-reductase catalytic, N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: