YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: DNF1

General Information:
Name(s) found: DNF1 / YER166W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1571 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: phospholipid translocation [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    intracellular protein transport [IGILink to PubMed article]
    endocytosis [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [ISSLink to PubMed article]
    phospholipid-translocating ATPase activity [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTFHGDGH APMSPFEDTF QFEDNSSNED THIAPTHFDD GATSNKYSRP QVSFNDETPK  60
   61 NKREDAEEFT FNDDTEYDNH SFQPTPKLNN GSGTFDDVEL DNDSGEPHTN YDGMKRFRMG 120
  121 TKRNKKGNPI MGRSKTLKWA RKNIPNPFED FTKDDIDPGA INRAQELRTV YYNMPLPKDM 180
  181 IDEEGNPIMQ YPRNKIRTTK YTPLTFLPKN ILFQFHNFAN VYFLVLIILG AFQIFGVTNP 240
  241 GLSAVPLVVI VIITAIKDAI EDSRRTVLDL EVNNTKTHIL EGVENENVST DNISLWRRFK 300
  301 KANSRLLFKF IQYCKEHLTE EGKKKRMQRK RHELRVQKTV GTSGPRSSLD SIDSYRVSAD 360
  361 YGRPSLDYDN LEQGAGEANI VDRSLPPRTD CKFAKNYWKG VKVGDIVRIH NNDEIPADII 420
  421 LLSTSDTDGA CYVETKNLDG ETNLKVRQSL KCTNTIRTSK DIARTKFWIE SEGPHSNLYT 480
  481 YQGNMKWRNL ADGEIRNEPI TINNVLLRGC TLRNTKWAMG VVMFTGGDTK IMLNSGITPT 540
  541 KKSRISRELN FSVVINFVLL FILCFVSGIA NGVYYDKKGR SRFSYEFGTI AGSAATNGFV 600
  601 SFWVAVILYQ SLVPISLYIS VEIIKTAQAA FIYGDVLLYN AKLDYPCTPK SWNISDDLGQ 660
  661 VEYIFSDKTG TLTQNVMEFK KCTINGVSYG RAYTEALAGL RKRQGIDVET EGRREKAEIA 720
  721 KDRDTMIDEL RALSGNSQFY PEEVTFVSKE FVRDLKGASG EVQQRCCEHF MLALALCHSV 780
  781 LVEANPDNPK KLDLKAQSPD EAALVATARD VGFSFVGKTK KGLIIEMQGI QKEFEILNIL 840
  841 EFNSSRKRMS CIVKIPGLNP GDEPRALLIC KGADSIIYSR LSRQSGSNSE AILEKTALHL 900
  901 EQYATEGLRT LCIAQRELSW SEYEKWNEKY DIAAASLANR EDELEVVADS IERELILLGG 960
  961 TAIEDRLQDG VPDCIELLAE AGIKLWVLTG DKVETAINIG FSCNLLNNEM ELLVIKTTGD1020
 1021 DVKEFGSEPS EIVDALLSKY LKEYFNLTGS EEEIFEAKKD HEFPKGNYAI VIDGDALKLA1080
 1081 LYGEDIRRKF LLLCKNCRAV LCCRVSPSQK AAVVKLVKDS LDVMTLAIGD GSNDVAMIQS1140
 1141 ADVGIGIAGE EGRQAVMCSD YAIGQFRYLA RLVLVHGRWS YKRLAEMIPE FFYKNMIFAL1200
 1201 ALFWYGIYND FDGSYLYEYT YMMFYNLAFT SLPVIFLGIL DQDVNDTISL VVPQLYRVGI1260
 1261 LRKEWNQRKF LWYMLDGLYQ SIICFFFPYL VYHKNMIVTS NGLGLDHRYF VGVYVTTIAV1320
 1321 ISCNTYVLLH QYRWDWFSGL FIALSCLVVF AWTGIWSSAI ASREFFKAAA RIYGAPSFWA1380
 1381 VFFVAVLFCL LPRFTYDSFQ KFFYPTDVEI VREMWQHGHF DHYPPGYDPT DPNRPKVTKA1440
 1441 GQHGEKIIEG IALSDNLGGS NYSRDSVVTE EIPMTFMHGE DGSPSGYQKQ ETWMTSPKET1500
 1501 QDLLQSPQFQ QAQTFGRGPS TNVRSSLDRT REQMIATNQL DNRYSVERAR TSLDLPGVTN1560
 1561 AASLIGTQQN N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ATP16 CDC60 DHH1 DNF1 GDH3
    View Details Qiu et al. (2008) DNF1 DNF2 FAT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DNF1 Huh WK, et al. (2003)
    View Data DNF1 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] MSA 1.245944 View MSA. No confident structure predictions are available.
    2 View Details [283..307]
    [383..539]    		 PSI-BLAST 1023.9794 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    3 View Details [308..372]
    [540..624]
    [1180..1418]    		 PSI-BLAST 1023.9794 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    4 View Details [373..382]
    [625..674]
    [967..1179]    		 PSI-BLAST 1023.9794 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    5 View Details [675..966] PSI-BLAST 1023.9794 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    6 View Details [1419..1571] MSA 1.16998 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle