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Protein Overview: MON1

General Information:
Name(s) found: MON1 / YGL124C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 644 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: autophagy [IMPLink to PubMed article]
    vesicle docking [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLNESYLDA EIPKGQLKHS KSGNFEGIPI VATTSEPTTS VNLDETFFKK APIAMPICDD  60
   61 HSVSKSTSVN SLNTTSLASR RSPLQTKKLQ AKNNLLSADL AKSNDDTTRA LNCPKKDFGP 120
  121 YLDSENDIRS RLAESIYSME TSIRGSELQR RPYVSNEIPN VFKFSKFNSN CKLNESQTLC 180
  181 DKNFFIFTSA GKPIYCMHGK DEQIMSYTGL VNTVISYFQV NGPSELKTIS TLTSGKRLTF 240
  241 LDKSPILLMA QSERGESSNE LLNQLDFLYS YILSSLSERQ LLRLFSKREN FDLRNYLEST 300
  301 DFENLDEICS LICNRMFPDL LLNSLQCLPF NHSSRLKLQN VVLQQLEKRQ DIPRGTLLYG 360
  361 LIIAPQNKLC CVLRPRGHTL HTTDLHLLFC LISHQFQNLD ETQELWVPIC FPKFNSSGFL 420
  421 YCYIKFLPND THSNEKSALV LISAQKDAFF SLKSFSDELI IKLEEEKLLK KINTSKGFKL 480
  481 SDIPAPMVHH FIYKSKQNVQ YVMPHFEVNS NIALDSSQGL EYELKLKTYY QQLHGTVVRD 540
  541 NGNLLSRSML NFVRWSSKDN EDLAMDETQM DFSELDEYII GNSSFKQESV NMVGMAWVTP 600
  601 TFELYLIGNN GIVDKRVLFK SARKVANWCQ KHESRLFISD GAVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CCZ1 MON1 YAP1
    View Details Qiu et al. (2008) AST2 MON1 REH1 UGO1 YDL133W YGK3 YGR149W YOR292C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MON1 Huh WK, et al. (2003)
    View Data MON1 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] deduced N/A No confident structure predictions are available.
    2 View Details [114..320] ORFEUS 7.04 Sigma2 adaptin (clathrin coat assembly protein AP17)
    3 View Details [321..412] deduced N/A No confident structure predictions are available.
    4 View Details [413..644] MSA 1.009968 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  1.65703073817987 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.47755255763729 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.815884494512385 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle