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View Structure Prediction Details

Protein: ENT3
Organism: Saccharomyces cerevisiae
Length: 408 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENT3.

Description E-value Query
Range		 Subject
Range
ENT3_YEAST - Epsin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENT3 PE=1 SV=1
gi|190409597 - gi|190409597|gb|EDV12862.1| epsin-3 [Saccharomyces cerevisiae RM11-1a]
gi|151945190 - gi|151945190|gb|EDN63441.1| epsin-like protein [Saccharomyces cerevisiae YJM789]
gi|207343773 - gi|207343773|gb|EDZ71130.1| YJR125Cp-like protein [Saccharomyces cerevisiae AWRI1631]
ENT3 - Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic betw...
 6.0E-91 [1..408] [1..408]
gi|3894395 - gi|3894395|gb|AAC78608.1| epsin 2a [Homo sapiens]
 9.0E-88 [10..408] [1..404]
SPCC794.11c - ENTH domain protein Ent3
YCTB_SCHPO - ENTH domain-containing protein C794.11c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP...
 1.0E-82 [2..396] [3..450]
EPN1_RAT - Epsin-1 OS=Rattus norvegicus GN=Epn1 PE=1 SV=1
 2.0E-80 [10..408] [1..406]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 3.0E-76 [8..352] [130..483]

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Predicted Domain #1
Region A:
Residues: [1-167] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEDTLANM SLYDAKKYFR KAQNVVFNYT EMEGKVREAT NNEPWGASST LMDQISQGTY  60
   61 NFREREEILS MIFRRFTEKA GSEWRQIYKA LQLLDYLIKH GSERFIDDTR NSINLIRILE 120
  121 TFHYIDSQGR DQGINVRTRV KALIELLSDD NKIRAERKKA RETAKKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 387.491979
Match: 1inzA_
Description: Epsin 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 7.05477548709703 bayes_pls_golite062009
binding 2.34501465852339 bayes_pls_golite062009
protein binding 1.97365365208963 bayes_pls_golite062009
phospholipid binding 1.38798066582556 bayes_pls_golite062009
phosphoinositide binding 1.26458267960741 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.20269437433936 bayes_pls_golite062009
lipid binding 0.176990783274449 bayes_pls_golite062009
GTPase binding 0.0887270623721197 bayes_pls_golite062009
small GTPase binding 0.0268749201897704 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [168-408] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGVAGGSASA DGSLNSKAGF TSTKVHGISV SADFDSDNED NEDGSFSQNG YNDNASRATS  60
   61 TPGQGKQEPE DFVDFFSSES SKPSKELIQE DEKKADEEED DDDEFSEFQS AVPVTNPANS 120
  121 FNLLNTSPIE GMPATTSSMP FYNSSTTDQG KITPAIAEPK KVDPFSSLFS TAKASAEAPS 180
  181 APKASQAKAA ASNPVSNSTT ALSTDQDDDD EFGEMHGGAV QQEQNTNNNH TSSKEIDLLS 240
  241 F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle