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View Structure Prediction Details

Protein: UBR2
Organism: Saccharomyces cerevisiae
Length: 1872 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBR2.

Description E-value Query
Range
Subject
Range
UBR1 - E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-e...
UBR1_YEAST - E3 ubiquitin-protein ligase UBR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBR1 PE...
0.0 [64..1467] [88..1409]
UBR1_KLULA - E3 ubiquitin-protein ligase UBR1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / ...
UBR1_KLULA - E3 ubiquitin-protein ligase UBR1 OS=Kluyveromyces lactis GN=UBR1 PE=3 SV=2
0.0 [65..1447] [80..1398]
ubr1 - N-end-recognizing protein Ubr1
UBR1_SCHPO - E3 ubiquitin-protein ligase ubr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubr1 PE=3...
0.0 [10..1440] [19..1430]
CE08535 - WBGene00016326 status:Partially_confirmed SW:P91133 protein_id:AAB42328.1
0.0 [94..1372] [12..1266]
UBR1_MOUSE - E3 ubiquitin-protein ligase UBR1 OS=Mus musculus GN=Ubr1 PE=1 SV=1
0.0 [454..1381] [341..1224]
UBR11_SCHPO - E3 ubiquitin-protein ligase ubr11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubr11 PE...
ubr11 - N-end-recognizing protein
0.0 [446..1419] [573..1532]
gi|2224639 - gi|2224639|dbj|BAA20806.1| KIAA0349 [Homo sapiens]
0.0 [604..1390] [1..762]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSDLSITN IRDFLTELPK LAKCEYSETT SYLLWKTLNL RLKHSDNDIN WRSLVSILNS  60
   61 EAWENEKYRD ILNGRKWRTL E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.905 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain

Predicted Domain #2
Region A:
Residues: [82-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FENDHHSVGN MHIGTACTRL CFPSETIYYC FTCSTNPLYE ICELCFDKEK HVNHSYVAKV  60
   61 VMRPEGRICH CGDPFAFNDP SDAFKCKNEL NN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 32.958607
Match: PF02207
Description: Putative zinc finger in N-recognin

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [174-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPISNDNSNV TDDENVISLL NYVLDFLIDV TVSYKEEAEA HSSERKASSL MHPNQNSITD  60
   61 DIMEKHECEP LVNDENFVFF DNNWSNTRKE AHMEWAIQIE EEECNVHYMD LASTITRILN 120
  121 TPVEYAISIT KALEDSHDVV TVLQSENFFE IDQIAKEFQK ENIVVHVRKA DDIFKRKLTD 180
  181 DLTDWLYSLC FKAATSLQNK YALRISMLDV WYSHFSKMRV SPTNTNPDFS KINLLGGFLI 240
  241 SNEDSDESWF KPWSLENIED ERISKILTNY NERLIRAHSP NTVSHFYNFY GSRFQYIIIN 300
  301 SINILSKKSK FKMLKIMASL FSLRDESRKF LAAQYIDVYL SVLYDAVASD AKECQVTLMS 360
  361 ILGQYTFQDP SIANMTISSG FIERTIRFAF TLMAFNPEDL MSYLPISLYN GFKLPTETIR 420
  421 NRRTIICFKD LCTIMSANTV PEELLSNEAI FNAIIESFSE FSNVLPLKRE TKEHVEVENF 480
  481 DFSAFYFFFS SILIMTDGYT RSISLVKDAA FRKQIVLKLL DVAQTREFES LTNSRKAISP 540
  541 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [714-1270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNASTNENDS NKATLSTVRE TICNYVAETI NFQVGVNTQY FFNPMSYLFK FVIQWSQCGR  60
   61 YEPIPASLTN YINLFEVFQD KQKALYISES ALSTLVLIGQ INVGFWVRNG TPITHQARMY 120
  121 TKYSMREFTY ISDIFNVQFS MAMCNPDELM VTYLSRWGLK HWANGVPMYD YPDTETTVAV 180
  181 VNECILLLIQ LLTEVRSLVM KSSKEGFERT FKSEIIHALC FDTCSYAQIV NCIPEHITKH 240
  241 PSFDIYLEKY ANYTSPVSLT DNGIFVLKEK YKDEIDPYYI GLSSSRRYDV EKNIRLNMAN 300
  301 LKKMKYEDTF VPAKKVKDLL KNTLFSGLYS ISSVNTFGLF LKNTLDHIIK YDYDNLLPRV 360
  361 VHLIHLCVVN NLNEFMGILW HEYAIVDTEF CHYHSIGSIL YYCLLKDNFS ESHGKIREIF 420
  421 RYLMETAPHV NVNSYLREQT TSYTPGILWP TKEDKSHKDK EFERKKHLAR LRKKKLMKKL 480
  481 AQQQMKFMEN NSVDTSDIST PRTTSPSLSP TRINAENSSN TINSCCDDDC VFCKMPKDDD 540
  541 VFVYFSYQER NICDHGI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1271-1570]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFTNPTDVNR INSLFSGKQT KDSAIQENPQ DDDGTRLKFT SCEPVLRACG HGSHTKCLSG  60
   61 HMKSIRGIQN QTTKNIPLSY GSGLIYCPVC NSLSNSFLPK TNDIDKRTSS QFFMCIEKRS 120
  121 EAEENLDPMS SICIKAAMIL GDLQGKKVTT IEDAYKVVNS VFINTISNTE LRLRSHKKEG 180
  181 KIVNMERISS QCILTLHLVC ELKSFIYKKF VNSKTFSSEI SRKIWNWNEF LIKGNNVNLL 240
  241 LYMSQNFDNI DGGKTPQPPN LCIYEMFKRR FHQLLLLLAR DMMRVNFYKD CRNKIKISSN 300
  301 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1571-1872]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEEPSTSFS YLFNTFKKYV DLFKPDDVRF DFTSLEKIKD FICSLLLESL SIFCRRTFLL  60
   61 FNIQYDDDGD GDNNNNRSNN FMDVKQREIE LIFRYFKLPN LTHFLKDFFY NELTQNIERY 120
  121 NDGNDNLRIQ QVIYDMVQNI NTRAYPSPEH IQLIELPLNL SKFSLDNDEI SNKCDKYEIA 180
  181 VCLLCGQKCH IQKSIALQGY LQGECTDHMR NGCEITSAYG VFLMTGTNAI YLSYGKRGTF 240
  241 YAAPYLSKYG ETNEDYKFGT PVYLNRARYA NLANEIVFGN MIPHIVFRLT DGSADLGGWE 300
  301 TM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.23450316335876 bayes_pls_golite062009
binding 2.14387047687719 bayes_pls_golite062009
DNA binding 2.04297552772596 bayes_pls_golite062009
transcription regulator activity 2.02735936435983 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.32633588604151 bayes_pls_golite062009
transcription factor activity 1.26194702122873 bayes_pls_golite062009
small conjugating protein ligase activity 1.15892915621711 bayes_pls_golite062009
protein binding 0.863483803868456 bayes_pls_golite062009
acid-amino acid ligase activity 0.74103129816245 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.201004090113231 bayes_pls_golite062009
sequence-specific DNA binding 0.111186019165274 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1017-1169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYEDTFVPA KKVKDLLKNT LFSGLYSISS VNTFGLFLKN TLDHIIKYDY DNLLPRVVHL  60
   61 IHLCVVNNLN EFMGILWHEY AIVDTEFCHY HSIGSILYYC LLKDNFSESH GKIREIFRYL 120
  121 METAPHVNVN SYLREQTTSY TPGILWPTKE DKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1170-1375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKDKEFERKK HLARLRKKKL MKKLAQQQMK FMENNSVDTS DISTPRTTSP SLSPTRINAE  60
   61 NSSNTINSCC DDDCVFCKMP KDDDVFVYFS YQERNICDHG IDFTNPTDVN RINSLFSGKQ 120
  121 TKDSAIQENP QDDDGTRLKF TSCEPVLRAC GHGSHTKCLS GHMKSIRGIQ NQTTKNIPLS 180
  181 YGSGLIYCPV CNSLSNSFLP KTNDID

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1376-1576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRTSSQFFMC IEKRSEAEEN LDPMSSICIK AAMILGDLQG KKVTTIEDAY KVVNSVFINT  60
   61 ISNTELRLRS HKKEGKIVNM ERISSQCILT LHLVCELKSF IYKKFVNSKT FSSEISRKIW 120
  121 NWNEFLIKGN NVNLLLYMSQ NFDNIDGGKT PQPPNLCIYE MFKRRFHQLL LLLARDMMRV 180
  181 NFYKDCRNKI KISSNGSEEP S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1577-1714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSFSYLFNTF KKYVDLFKPD DVRFDFTSLE KIKDFICSLL LESLSIFCRR TFLLFNIQYD  60
   61 DDGDGDNNNN RSNNFMDVKQ REIELIFRYF KLPNLTHFLK DFFYNELTQN IERYNDGNDN 120
  121 LRIQQVIYDM VQNINTRA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1715-1872]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPSPEHIQLI ELPLNLSKFS LDNDEISNKC DKYEIAVCLL CGQKCHIQKS IALQGYLQGE  60
   61 CTDHMRNGCE ITSAYGVFLM TGTNAIYLSY GKRGTFYAAP YLSKYGETNE DYKFGTPVYL 120
  121 NRARYANLAN EIVFGNMIPH IVFRLTDGSA DLGGWETM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle