YRC Public Data Repository - Protein Structure Prediction

Protein:	TOA2
Organism:	Saccharomyces cerevisiae
Length:	122 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOA2.

Description	E-value	Query Range	Subject Range
T2AG_YEAST - Transcription initiation factor IIA subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288... TOA2 - TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator... gi\|190409771 - gi\|190409771\|gb\|EDV13036.1\| transcription initiation factor IIA small chain [Saccharomyces cerevisia... gi\|151941488 - gi\|151941488\|gb\|EDN59851.1\| transcription factor IIA subunit [Saccharomyces cerevisiae YJM789]	3.0E-45	[1..122]	[1..122]
T2AG_ARATH - Transcription initiation factor IIA subunit 2 OS=Arabidopsis thaliana GN=TFIIA-S PE=2 SV=2	1.0E-39	[7..119]	[4..102]
GTF2A2 - general transcription factor IIA, 2, 12kDa gi\|114657364, gi... - gi\|55642219\|ref\|XP_510452.1\| PREDICTED: general transcription factor IIA, 2, 12kDa isoform 4 [Pan tr... gi\|83035115, gi\|... - gi\|83035115\|ref\|NP_001032708.1\| general transcription factor IIA, 2, 12kDa [Bos taurus], gi\|81674371... gi\|123980684, gi... - gi\|60656075\|gb\|AAX32601.1\| general transcription factor IIA 2 [synthetic construct], gi\|208966358\|db...	6.0E-39	[7..121]	[3..103]
gi\|57108247 - gi\|57108247\|ref\|XP_535502.1\| PREDICTED: similar to general transcription factor Iia 2 isoform 1 [Can... CCDS10173.1_1 - null tr\|M3WHV3\|M3WHV3... - Transcription initiation factor IIA subunit 2 OS=Felis catus GN=GTF2A2 PE=3 SV=1 T2AG_MOUSE - Transcription initiation factor IIA subunit 2 OS=Mus musculus GN=Gtf2a2 PE=1 SV=2 T2AG_RAT - Transcription initiation factor IIA subunit 2 OS=Rattus norvegicus GN=Gtf2a2 PE=3 SV=1 gi\|109081344, gi... - gi\|109081344\|ref\|XP_001100320.1\| PREDICTED: similar to general transcription factor Iia 2 isoform 3 ... gi\|149691901 - gi\|149691901\|ref\|XP_001500046.1\| PREDICTED: similar to TFIIA small subunit [Equus caballus]	8.0E-39	[7..121]	[3..103]
gi\|55585041 - gb\|AAV53716.1\| transcription factor IIA gamma subunit [Oryza sativa (indica cultivar-group)] T2AG_ORYSJ - Transcription initiation factor IIA subunit 2 OS=Oryza sativa subsp. japonica GN=TFIIAy PE=3 SV=1 T2AG_ORYSI - Transcription initiation factor IIA subunit 2 OS=Oryza sativa subsp. indica GN=TFIIAy PE=3 SV=2 T2AG_ORYSA - Transcription initiation factor IIA gamma chain (TFIIA-gamma) - Oryza sativa (Rice)	8.0E-39	[7..119]	[4..102]
gi\|209730768, gi... - gi\|209736464\|gb\|ACI69101.1\| Transcription initiation factor IIA subunit 2 [Salmo salar], gi\|20973076... T2AG_ONCMY - Transcription initiation factor IIA subunit 2 OS=Oncorhynchus mykiss GN=gtf2a2 PE=3 SV=1	2.0E-38	[7..121]	[3..103]
TfIIA-S-PA - The gene Transcription-factor-IIA-S is referred to in FlyBase by the symbol Dmel\TfIIA-S (CG5163, FB...	1.0E-37	[7..122]	[3..105]
T2AG_PAROL - Transcription initiation factor IIA subunit 2 OS=Paralichthys olivaceus GN=gtf2a2 PE=3 SV=1	5.0E-37	[7..120]	[3..102]

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Predicted Domain #1

Region A:
Residues: [1-57]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVPGYYELY RRSTIGNSLV DALDTLISDG RIEASLAMRV LETFDKVVAE TLKDNTQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	639.28043
Match:	1ytfD_
Description:	Small chain TOA2, N-terminal domain; Small chain TOA2, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	10.9702263885595	bayes_pls_golite062009
RNA polymerase II transcription factor activity	5.06993130505706	bayes_pls_golite062009
transcription regulator activity	4.7915315980149	bayes_pls_golite062009
transcription activator activity	2.75298328621175	bayes_pls_golite062009
nucleic acid binding	2.26583234267697	bayes_pls_golite062009
DNA binding	2.12151270115091	bayes_pls_golite062009
transcription coactivator activity	2.10703866415858	bayes_pls_golite062009
binding	1.9212205923594	bayes_pls_golite062009
protein binding	1.54756881357956	bayes_pls_golite062009
transcription factor binding	1.31659763916181	bayes_pls_golite062009
transcription cofactor activity	1.15899255380593	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [58-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKLTVKGNLD TYGFCDDVWT FIVKNCQVTV EDSHRDASQN GSGDSQSVIS VDKLRIVACN  60
   61 SKKSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	639.28043
Match:	1ytfD_
Description:	Small chain TOA2, N-terminal domain; Small chain TOA2, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: